Fluorescence diagnostics of head and neck cancer utilizing oral administration of δ-amino levulinic acid

K. Svanberg; I. Wang; R. Rydell; Elner; J. Wennerberg; L. Pais Clemente; E. Cardosa; R. Pratas; M. Pais Clemente; S. Andersson-Engels; S. Svanberg

doi:10.1117/12.203438

Fluorescence diagnostics of head and neck cancer utilizing oral administration of δ-amino levulinic acid

K. Svanberg
, I. Wang
, R. Rydell
, Elner
, J. Wennerberg
, L. Pais Clemente
, E. Cardosa
, R. Pratas
, M. Pais Clemente
, S. Andersson-Engels
, S. Svanberg

Research output: Contribution to journal › Article › peer-review

Abstract

Tissue fluorescence measurements utilizing a point monitoring fluorosensor and a multi-colour fluorescence imaging system were performed in patients with various malignant tumours in the head and neck region. Also precancerous lesions were investigated and characterized by means of laser-induced fluorescence. Oral administration of low-dose 5-amino levulinic acid was used for the induction of protoporphyrin IX, which exhibits a strong fluorescence in the red wavelength region. The blue-green fluorescence emitted from the tissue natural chromophores was also utilized for tumour demarcation. By incorporating both Protoporphyrin IX and natural fluorescence in a tumour demarcation criterion a tumour demarcation with a tumour-to-normalsurrounding-tissue of about 5-10:1 contrast was acheived. Hypertrophic tissue did not exhibit tumour specific signals.

Original language	English
Pages (from-to)	129-141
Number of pages	13
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2371
DOIs	https://doi.org/10.1117/12.203438
Publication status	Published - 1 Mar 1995
Externally published	Yes
Event	5th International Photodynamic Association Biennial Meeting 1994 - Amelia Island, United States Duration: 21 Sep 1994 → 24 Sep 1994

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ENT-malignancies
Laser-induced fluorescence
Oral ALA
Protoporphyrin IX sensitization
Tumour diagnostics

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10.1117/12.203438

Cite this

Svanberg, K., Wang, I., Rydell, R., Elner, Wennerberg, J., Pais Clemente, L., Cardosa, E., Pratas, R., Pais Clemente, M., Andersson-Engels, S., & Svanberg, S. (1995). Fluorescence diagnostics of head and neck cancer utilizing oral administration of δ-amino levulinic acid. Proceedings of SPIE - The International Society for Optical Engineering, 2371, 129-141. https://doi.org/10.1117/12.203438

@article{c6b810b247c3457bbcbd265a381e5419,

title = "Fluorescence diagnostics of head and neck cancer utilizing oral administration of δ-amino levulinic acid",

abstract = "Tissue fluorescence measurements utilizing a point monitoring fluorosensor and a multi-colour fluorescence imaging system were performed in patients with various malignant tumours in the head and neck region. Also precancerous lesions were investigated and characterized by means of laser-induced fluorescence. Oral administration of low-dose 5-amino levulinic acid was used for the induction of protoporphyrin IX, which exhibits a strong fluorescence in the red wavelength region. The blue-green fluorescence emitted from the tissue natural chromophores was also utilized for tumour demarcation. By incorporating both Protoporphyrin IX and natural fluorescence in a tumour demarcation criterion a tumour demarcation with a tumour-to-normalsurrounding-tissue of about 5-10:1 contrast was acheived. Hypertrophic tissue did not exhibit tumour specific signals.",

keywords = "ENT-malignancies, Laser-induced fluorescence, Oral ALA, Protoporphyrin IX sensitization, Tumour diagnostics",

author = "K. Svanberg and I. Wang and R. Rydell and Elner and J. Wennerberg and \{Pais Clemente\}, L. and E. Cardosa and R. Pratas and \{Pais Clemente\}, M. and S. Andersson-Engels and S. Svanberg",

note = "Publisher Copyright: {\textcopyright} 1995 SPIE.; 5th International Photodynamic Association Biennial Meeting 1994 ; Conference date: 21-09-1994 Through 24-09-1994",

year = "1995",

month = mar,

day = "1",

doi = "10.1117/12.203438",

language = "English",

volume = "2371",

pages = "129--141",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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}

Svanberg, K, Wang, I, Rydell, R, Elner, Wennerberg, J, Pais Clemente, L, Cardosa, E, Pratas, R, Pais Clemente, M, Andersson-Engels, S & Svanberg, S 1995, 'Fluorescence diagnostics of head and neck cancer utilizing oral administration of δ-amino levulinic acid', Proceedings of SPIE - The International Society for Optical Engineering, vol. 2371, pp. 129-141. https://doi.org/10.1117/12.203438

TY - JOUR

T1 - Fluorescence diagnostics of head and neck cancer utilizing oral administration of δ-amino levulinic acid

AU - Svanberg, K.

AU - Wang, I.

AU - Rydell, R.

AU - Elner,

AU - Wennerberg, J.

AU - Pais Clemente, L.

AU - Cardosa, E.

AU - Pratas, R.

AU - Pais Clemente, M.

AU - Andersson-Engels, S.

AU - Svanberg, S.

PY - 1995/3/1

Y1 - 1995/3/1

N2 - Tissue fluorescence measurements utilizing a point monitoring fluorosensor and a multi-colour fluorescence imaging system were performed in patients with various malignant tumours in the head and neck region. Also precancerous lesions were investigated and characterized by means of laser-induced fluorescence. Oral administration of low-dose 5-amino levulinic acid was used for the induction of protoporphyrin IX, which exhibits a strong fluorescence in the red wavelength region. The blue-green fluorescence emitted from the tissue natural chromophores was also utilized for tumour demarcation. By incorporating both Protoporphyrin IX and natural fluorescence in a tumour demarcation criterion a tumour demarcation with a tumour-to-normalsurrounding-tissue of about 5-10:1 contrast was acheived. Hypertrophic tissue did not exhibit tumour specific signals.

AB - Tissue fluorescence measurements utilizing a point monitoring fluorosensor and a multi-colour fluorescence imaging system were performed in patients with various malignant tumours in the head and neck region. Also precancerous lesions were investigated and characterized by means of laser-induced fluorescence. Oral administration of low-dose 5-amino levulinic acid was used for the induction of protoporphyrin IX, which exhibits a strong fluorescence in the red wavelength region. The blue-green fluorescence emitted from the tissue natural chromophores was also utilized for tumour demarcation. By incorporating both Protoporphyrin IX and natural fluorescence in a tumour demarcation criterion a tumour demarcation with a tumour-to-normalsurrounding-tissue of about 5-10:1 contrast was acheived. Hypertrophic tissue did not exhibit tumour specific signals.

KW - ENT-malignancies

KW - Laser-induced fluorescence

KW - Oral ALA

KW - Protoporphyrin IX sensitization

KW - Tumour diagnostics

UR - https://www.scopus.com/pages/publications/0029461407

U2 - 10.1117/12.203438

DO - 10.1117/12.203438

M3 - Article

AN - SCOPUS:0029461407

SN - 0277-786X

VL - 2371

SP - 129

EP - 141

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - 5th International Photodynamic Association Biennial Meeting 1994

Y2 - 21 September 1994 through 24 September 1994

ER -

Fluorescence diagnostics of head and neck cancer utilizing oral administration of δ-amino levulinic acid

Abstract

UN SDGs

Keywords

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