Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

Alexandra Oranth; Christian Schultheis; Oleg Tolstenkov; Karen Erbguth; Jatin Nagpal; David Hain; Martin Brauner; Sebastian Wabnig; Wagner Steuer Costa; Rebecca D. McWhirter; Sven Zels; Sierra Palumbos; David M. Miller; Isabel Beets; Alexander Gottschalk

doi:10.1016/j.neuron.2018.10.024

Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

Alexandra Oranth
, Christian Schultheis
, Oleg Tolstenkov
, Karen Erbguth
, Jatin Nagpal
, David Hain
, Martin Brauner
, Sebastian Wabnig
, Wagner Steuer Costa
, Rebecca D. McWhirter
, Sven Zels
, Sierra Palumbos
, David M. Miller
, Isabel Beets
, Alexander Gottschalk

Research output: Contribution to journal › Article › peer-review

Abstract

In this study of C. elegans food response behavior, the underlying circuitry is identified by dopaminergic neurons signaling the presence of food to interneurons that release neuropeptides and regulate locomotion by conferring distinct motoneuron responses via specific neuropeptide receptor expression.

Original language	English
Pages (from-to)	1414-1428.e10
Journal	Neuron
Volume	100
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2018.10.024
Publication status	Published - 19 Dec 2018
Externally published	Yes

Keywords

behavioral quantification
behavioral switching
Ca2+ imaging
channelrhodopsin-2
FMRFamide neuropeptides
halorhodopsin
optogenetics
premotor navigational regulation
sensory integration
video tracking

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10.1016/j.neuron.2018.10.024

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Oranth, A., Schultheis, C., Tolstenkov, O., Erbguth, K., Nagpal, J., Hain, D., Brauner, M., Wabnig, S., Steuer Costa, W., McWhirter, R. D., Zels, S., Palumbos, S., Miller, D. M., Beets, I., & Gottschalk, A. (2018). Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network. Neuron, 100(6), 1414-1428.e10. https://doi.org/10.1016/j.neuron.2018.10.024

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title = "Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network",

abstract = "In this study of C. elegans food response behavior, the underlying circuitry is identified by dopaminergic neurons signaling the presence of food to interneurons that release neuropeptides and regulate locomotion by conferring distinct motoneuron responses via specific neuropeptide receptor expression.",

keywords = "behavioral quantification, behavioral switching, Ca2+ imaging, channelrhodopsin-2, FMRFamide neuropeptides, halorhodopsin, optogenetics, premotor navigational regulation, sensory integration, video tracking",

author = "Alexandra Oranth and Christian Schultheis and Oleg Tolstenkov and Karen Erbguth and Jatin Nagpal and David Hain and Martin Brauner and Sebastian Wabnig and \{Steuer Costa\}, Wagner and McWhirter, \{Rebecca D.\} and Sven Zels and Sierra Palumbos and Miller, \{David M.\} and Isabel Beets and Alexander Gottschalk",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = dec,

day = "19",

doi = "10.1016/j.neuron.2018.10.024",

language = "English",

volume = "100",

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Oranth, A, Schultheis, C, Tolstenkov, O, Erbguth, K, Nagpal, J, Hain, D, Brauner, M, Wabnig, S, Steuer Costa, W, McWhirter, RD, Zels, S, Palumbos, S, Miller, DM, Beets, I & Gottschalk, A 2018, 'Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network', Neuron, vol. 100, no. 6, pp. 1414-1428.e10. https://doi.org/10.1016/j.neuron.2018.10.024

TY - JOUR

T1 - Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

AU - Oranth, Alexandra

AU - Schultheis, Christian

AU - Tolstenkov, Oleg

AU - Erbguth, Karen

AU - Nagpal, Jatin

AU - Hain, David

AU - Brauner, Martin

AU - Wabnig, Sebastian

AU - Steuer Costa, Wagner

AU - McWhirter, Rebecca D.

AU - Zels, Sven

AU - Palumbos, Sierra

AU - Miller, David M.

AU - Beets, Isabel

AU - Gottschalk, Alexander

PY - 2018/12/19

Y1 - 2018/12/19

N2 - In this study of C. elegans food response behavior, the underlying circuitry is identified by dopaminergic neurons signaling the presence of food to interneurons that release neuropeptides and regulate locomotion by conferring distinct motoneuron responses via specific neuropeptide receptor expression.

AB - In this study of C. elegans food response behavior, the underlying circuitry is identified by dopaminergic neurons signaling the presence of food to interneurons that release neuropeptides and regulate locomotion by conferring distinct motoneuron responses via specific neuropeptide receptor expression.

KW - behavioral quantification

KW - behavioral switching

KW - Ca2+ imaging

KW - channelrhodopsin-2

KW - FMRFamide neuropeptides

KW - halorhodopsin

KW - optogenetics

KW - premotor navigational regulation

KW - sensory integration

KW - video tracking

UR - https://www.scopus.com/pages/publications/85058892433

U2 - 10.1016/j.neuron.2018.10.024

DO - 10.1016/j.neuron.2018.10.024

M3 - Article

C2 - 30392795

AN - SCOPUS:85058892433

SN - 0896-6273

VL - 100

SP - 1414-1428.e10

JO - Neuron

JF - Neuron

IS - 6

ER -

Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

Abstract

Keywords

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