Further evidence for plasma progranulin as a biomarker in bipolar disorder

Sarah Kittel-Schneider; Johannes Weigl; Julia Volkert; Alexandra Geßner; Brigitte Schmidt; Susanne Hempel; Tilman Kiel; David G. Olmes; Jasmin Bartl; Heike Weber; Juliane Kopf; Andreas Reif

doi:10.1016/j.jad.2014.01.006

Further evidence for plasma progranulin as a biomarker in bipolar disorder

Sarah Kittel-Schneider
, Johannes Weigl
, Julia Volkert
, Alexandra Geßner
, Brigitte Schmidt
, Susanne Hempel
, Tilman Kiel
, David G. Olmes
, Jasmin Bartl
, Heike Weber
, Juliane Kopf
, Andreas Reif

Research output: Contribution to journal › Article › peer-review

Abstract

Background A recent study suggested that progranulin (encoded by the fronto-temporal dementia risk gene GRN) plasma levels are decreased in bipolar disorder (BD). Replication of this finding is however lacking. Methods Progranulin plasma levels of bipolar patients (n=104) and healthy controls (n=80) were measured by enzyme-linked immunosorbent assay (ELISA). Participants were also genotyped for three single nucleotide polymorphisms (SNPs) in the GRN gene (rs2879096, rs4792938 and rs5848), and the effect of genetic variation on progranulin levels was examined. Results Plasma progranulin levels were decreased in BD (ANCOVA, p=0.001). Furthermore, age was significantly and positively correlated with plasma progranulin (Pearson).

Original language	English
Pages (from-to)	87-91
Number of pages	5
Journal	Journal of Affective Disorders
Volume	157
DOIs	https://doi.org/10.1016/j.jad.2014.01.006
Publication status	Published - 20 Mar 2014
Externally published	Yes

Keywords

Biomarker
Bipolar disorder
Genetic variants
Inflammation
Neurodegeneration
Progranulin

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10.1016/j.jad.2014.01.006

Cite this

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title = "Further evidence for plasma progranulin as a biomarker in bipolar disorder",

abstract = "Background A recent study suggested that progranulin (encoded by the fronto-temporal dementia risk gene GRN) plasma levels are decreased in bipolar disorder (BD). Replication of this finding is however lacking. Methods Progranulin plasma levels of bipolar patients (n=104) and healthy controls (n=80) were measured by enzyme-linked immunosorbent assay (ELISA). Participants were also genotyped for three single nucleotide polymorphisms (SNPs) in the GRN gene (rs2879096, rs4792938 and rs5848), and the effect of genetic variation on progranulin levels was examined. Results Plasma progranulin levels were decreased in BD (ANCOVA, p=0.001). Furthermore, age was significantly and positively correlated with plasma progranulin (Pearson).",

keywords = "Biomarker, Bipolar disorder, Genetic variants, Inflammation, Neurodegeneration, Progranulin",

author = "Sarah Kittel-Schneider and Johannes Weigl and Julia Volkert and Alexandra Ge{\ss}ner and Brigitte Schmidt and Susanne Hempel and Tilman Kiel and Olmes, \{David G.\} and Jasmin Bartl and Heike Weber and Juliane Kopf and Andreas Reif",

year = "2014",

month = mar,

day = "20",

doi = "10.1016/j.jad.2014.01.006",

language = "English",

volume = "157",

pages = "87--91",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Further evidence for plasma progranulin as a biomarker in bipolar disorder

AU - Kittel-Schneider, Sarah

AU - Weigl, Johannes

AU - Volkert, Julia

AU - Geßner, Alexandra

AU - Schmidt, Brigitte

AU - Hempel, Susanne

AU - Kiel, Tilman

AU - Olmes, David G.

AU - Bartl, Jasmin

AU - Weber, Heike

AU - Kopf, Juliane

AU - Reif, Andreas

PY - 2014/3/20

Y1 - 2014/3/20

N2 - Background A recent study suggested that progranulin (encoded by the fronto-temporal dementia risk gene GRN) plasma levels are decreased in bipolar disorder (BD). Replication of this finding is however lacking. Methods Progranulin plasma levels of bipolar patients (n=104) and healthy controls (n=80) were measured by enzyme-linked immunosorbent assay (ELISA). Participants were also genotyped for three single nucleotide polymorphisms (SNPs) in the GRN gene (rs2879096, rs4792938 and rs5848), and the effect of genetic variation on progranulin levels was examined. Results Plasma progranulin levels were decreased in BD (ANCOVA, p=0.001). Furthermore, age was significantly and positively correlated with plasma progranulin (Pearson).

AB - Background A recent study suggested that progranulin (encoded by the fronto-temporal dementia risk gene GRN) plasma levels are decreased in bipolar disorder (BD). Replication of this finding is however lacking. Methods Progranulin plasma levels of bipolar patients (n=104) and healthy controls (n=80) were measured by enzyme-linked immunosorbent assay (ELISA). Participants were also genotyped for three single nucleotide polymorphisms (SNPs) in the GRN gene (rs2879096, rs4792938 and rs5848), and the effect of genetic variation on progranulin levels was examined. Results Plasma progranulin levels were decreased in BD (ANCOVA, p=0.001). Furthermore, age was significantly and positively correlated with plasma progranulin (Pearson).

KW - Biomarker

KW - Bipolar disorder

KW - Genetic variants

KW - Inflammation

KW - Neurodegeneration

KW - Progranulin

UR - https://www.scopus.com/pages/publications/84893872715

U2 - 10.1016/j.jad.2014.01.006

DO - 10.1016/j.jad.2014.01.006

M3 - Article

C2 - 24581833

AN - SCOPUS:84893872715

SN - 0165-0327

VL - 157

SP - 87

EP - 91

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Further evidence for plasma progranulin as a biomarker in bipolar disorder

Abstract

Keywords

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