TY - JOUR
T1 - Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3
AU - McNeill, Rhiannon V.
AU - Radtke, Franziska
AU - Nieberler, Matthias
AU - Koreny, Carolin
AU - Chiocchetti, Andreas G.
AU - Kittel-Schneider, Sarah
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/3
Y1 - 2023/3
N2 - Single nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility of using magnetic activated cell sorting to allow the unbiased selection of fully reprogrammed iPSCs.
AB - Single nucleotide polymorphisms (SNPs) in the ADGRL3 gene have been significantly associated with the development of ADHD, the aetiology of which remains poorly understood. The rs1397547 SNP has additionally been associated with significantly altered ADGRL3 transcription. We therefore generated iPSCs from two wild type ADHD patients, and two ADHD patients heterozygous for the risk SNP. With this resource we aim to facilitate further investigation into the complex and heterogenous pathology of ADHD. Furthermore, we demonstrate the feasibility of using magnetic activated cell sorting to allow the unbiased selection of fully reprogrammed iPSCs.
UR - https://www.scopus.com/pages/publications/85146155327
U2 - 10.1016/j.scr.2023.103016
DO - 10.1016/j.scr.2023.103016
M3 - Article
C2 - 36640473
AN - SCOPUS:85146155327
SN - 1873-5061
VL - 67
JO - Stem Cell Research
JF - Stem Cell Research
M1 - 103016
ER -
