TY - JOUR
T1 - Generation of human induced pluripotent stem cell lines (hiPSC) from one bipolar disorder patient carrier of a DGKH risk haplotype and one non-risk-variant-carrier bipolar disorder patient
AU - Palladino, Viola Stella
AU - Subrata, Nadia Omega Cipta
AU - Geburtig-Chiocchetti, Andreas
AU - McNeill, Rhiannon
AU - Hoffmann, Per
AU - Reif, Andreas
AU - Kittel-Schneider, Sarah
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2018/10
Y1 - 2018/10
N2 - Fibroblasts were isolated from skin biopsies from two patients with bipolar I disorder. One patient was a 26 year old female carrying a risk haplotype in the DGKH (diacylglycerol kinase eta) gene and the other was a non-carrier 27 year old male. Patient fibroblasts were reprogrammed into human induced pluripotent stem cells (hiPSCs) by using a Sendai virus vector. DGKH-risk haplotype and non-risk haplotype hiPSCs showed expression of pluripotency markers and were able to differentiate into cells of the three germ layers. These cell models are useful to investigate the role of risk gene variants in bipolar disorder. Resource table.
AB - Fibroblasts were isolated from skin biopsies from two patients with bipolar I disorder. One patient was a 26 year old female carrying a risk haplotype in the DGKH (diacylglycerol kinase eta) gene and the other was a non-carrier 27 year old male. Patient fibroblasts were reprogrammed into human induced pluripotent stem cells (hiPSCs) by using a Sendai virus vector. DGKH-risk haplotype and non-risk haplotype hiPSCs showed expression of pluripotency markers and were able to differentiate into cells of the three germ layers. These cell models are useful to investigate the role of risk gene variants in bipolar disorder. Resource table.
UR - https://www.scopus.com/pages/publications/85053818556
U2 - 10.1016/j.scr.2018.09.008
DO - 10.1016/j.scr.2018.09.008
M3 - Article
C2 - 30266033
AN - SCOPUS:85053818556
SN - 1873-5061
VL - 32
SP - 104
EP - 109
JO - Stem Cell Research
JF - Stem Cell Research
ER -