Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment

Cristine Marie Yde Ohki; Natalie Monet Walter; Michelle Rickli; Cedric Iseli; Anna Maria Werling; Christian Döring; Belén Rubio; Per Hoffmann; Stefan Herms; Susanne Walitza; Edna Grünblatt

doi:10.1016/j.scr.2024.103546

Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment

Cristine Marie Yde Ohki
, Natalie Monet Walter
, Michelle Rickli
, Cedric Iseli
, Anna Maria Werling
, Christian Döring
, Belén Rubio
, Per Hoffmann
, Stefan Herms
, Susanne Walitza
, Edna Grünblatt

Research output: Contribution to journal › Article › peer-review

Abstract

As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a public health concern. Methylphenidate (MPH) is the drug of choice for ADHD; however, not all patients respond fully to this treatment. Therefore, exploring the underlying molecular mechanisms involved in ADHD and potential novel therapeutic targets is crucial. Here, we generated induced pluripotent stem cells (iPSCs) from Peripheral Blood Mononuclear Cells (PBMCs) retrieved from four ADHD patients (two MPH responders and two non-responders) using Sendai virus. These lines might be helpful for the in vitro investigation of ADHD pathophysiology in a patient-specific manner.

Original language	English
Article number	103546
Journal	Stem Cell Research
Volume	81
DOIs	https://doi.org/10.1016/j.scr.2024.103546
Publication status	Published - Dec 2024
Externally published	Yes

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title = "Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment",

abstract = "As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a public health concern. Methylphenidate (MPH) is the drug of choice for ADHD; however, not all patients respond fully to this treatment. Therefore, exploring the underlying molecular mechanisms involved in ADHD and potential novel therapeutic targets is crucial. Here, we generated induced pluripotent stem cells (iPSCs) from Peripheral Blood Mononuclear Cells (PBMCs) retrieved from four ADHD patients (two MPH responders and two non-responders) using Sendai virus. These lines might be helpful for the in vitro investigation of ADHD pathophysiology in a patient-specific manner.",

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year = "2024",

month = dec,

doi = "10.1016/j.scr.2024.103546",

language = "English",

volume = "81",

journal = "Stem Cell Research",

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T1 - Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment

AU - Yde Ohki, Cristine Marie

AU - Walter, Natalie Monet

AU - Rickli, Michelle

AU - Iseli, Cedric

AU - Werling, Anna Maria

AU - Döring, Christian

AU - Rubio, Belén

AU - Hoffmann, Per

AU - Herms, Stefan

AU - Walitza, Susanne

AU - Grünblatt, Edna

PY - 2024/12

Y1 - 2024/12

N2 - As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a public health concern. Methylphenidate (MPH) is the drug of choice for ADHD; however, not all patients respond fully to this treatment. Therefore, exploring the underlying molecular mechanisms involved in ADHD and potential novel therapeutic targets is crucial. Here, we generated induced pluripotent stem cells (iPSCs) from Peripheral Blood Mononuclear Cells (PBMCs) retrieved from four ADHD patients (two MPH responders and two non-responders) using Sendai virus. These lines might be helpful for the in vitro investigation of ADHD pathophysiology in a patient-specific manner.

AB - As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a public health concern. Methylphenidate (MPH) is the drug of choice for ADHD; however, not all patients respond fully to this treatment. Therefore, exploring the underlying molecular mechanisms involved in ADHD and potential novel therapeutic targets is crucial. Here, we generated induced pluripotent stem cells (iPSCs) from Peripheral Blood Mononuclear Cells (PBMCs) retrieved from four ADHD patients (two MPH responders and two non-responders) using Sendai virus. These lines might be helpful for the in vitro investigation of ADHD pathophysiology in a patient-specific manner.

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DO - 10.1016/j.scr.2024.103546

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VL - 81

JO - Stem Cell Research

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ER -

Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment

Abstract

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