TY - JOUR
T1 - Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging
AU - Turroni, Francesca
AU - Bottacini, Francesca
AU - Foroni, Elena
AU - Mulder, Imke
AU - Kim, Jae Han
AU - Zomer, Aldert
AU - Sánchez, Borja
AU - Bidossi, Alessandro
AU - Ferrarini, Alberto
AU - Giubellini, Vanessa
AU - Delledonne, Massimo
AU - Henrissat, Bernard
AU - Coutinho, Pedro
AU - Oggioni, Marco
AU - Fitzgerald, Gerald F.
AU - Mills, David
AU - Margolles, Abelardo
AU - Kelly, Denise
AU - Van Sinderen, Douwe
AU - Ventura, Marco
PY - 2010/11/9
Y1 - 2010/11/9
N2 - The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.
AB - The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.
KW - Coevolution
KW - Genomics
KW - Host-glycans metabolism
KW - Human gut intestinal bacteria
KW - Mucin
UR - https://www.scopus.com/pages/publications/78650609691
U2 - 10.1073/pnas.1011100107
DO - 10.1073/pnas.1011100107
M3 - Article
AN - SCOPUS:78650609691
SN - 0027-8424
VL - 107
SP - 19514
EP - 19519
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 45
ER -