Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

Kheshwant S. Gill; Philana Fernandes; Tracey R. O'Donovan; Sharon L. McKenna; Kishore K. Doddakula; Derek G. Power; Declan M. Soden; Patrick F. Forde

doi:10.1016/j.bbcan.2016.06.005

Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

Kheshwant S. Gill
, Philana Fernandes
, Tracey R. O'Donovan
, Sharon L. McKenna
, Kishore K. Doddakula
, Derek G. Power
, Declan M. Soden
, Patrick F. Forde

University College Cork

Research output: Contribution to journal › Review article › peer-review

Abstract

Increased glycolysis is the main source of energy supply in cancer cells that use this metabolic pathway for ATP generation. Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of the “hallmarks of cancer”. The immune system can prevent tumour growth by eliminating cancer cells but this editing process ultimately results in poorly immunogenic cells remaining allowing for unchallenged tumour growth. In this review we look at the glycolysis pathway as a target for cancer treatments. We also examine the interplay between the glycolysis modulation and the immune response as an anti-cancer therapy.

Original language	English
Pages (from-to)	87-105
Number of pages	19
Journal	Biochimica et Biophysica Acta - Reviews on Cancer
Volume	1866
Issue number	1
DOIs	https://doi.org/10.1016/j.bbcan.2016.06.005
Publication status	Published - 1 Aug 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Electroporation
Glycolysis
Glycolytic modulator
Immune-metabolic interaction

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10.1016/j.bbcan.2016.06.005

Cite this

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title = "Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response",

abstract = "Increased glycolysis is the main source of energy supply in cancer cells that use this metabolic pathway for ATP generation. Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of the “hallmarks of cancer”. The immune system can prevent tumour growth by eliminating cancer cells but this editing process ultimately results in poorly immunogenic cells remaining allowing for unchallenged tumour growth. In this review we look at the glycolysis pathway as a target for cancer treatments. We also examine the interplay between the glycolysis modulation and the immune response as an anti-cancer therapy.",

keywords = "Electroporation, Glycolysis, Glycolytic modulator, Immune-metabolic interaction",

author = "Gill, \{Kheshwant S.\} and Philana Fernandes and O'Donovan, \{Tracey R.\} and McKenna, \{Sharon L.\} and Doddakula, \{Kishore K.\} and Power, \{Derek G.\} and Soden, \{Declan M.\} and Forde, \{Patrick F.\}",

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doi = "10.1016/j.bbcan.2016.06.005",

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T1 - Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

AU - Gill, Kheshwant S.

AU - Fernandes, Philana

AU - O'Donovan, Tracey R.

AU - McKenna, Sharon L.

AU - Doddakula, Kishore K.

AU - Power, Derek G.

AU - Soden, Declan M.

AU - Forde, Patrick F.

PY - 2016/8/1

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N2 - Increased glycolysis is the main source of energy supply in cancer cells that use this metabolic pathway for ATP generation. Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of the “hallmarks of cancer”. The immune system can prevent tumour growth by eliminating cancer cells but this editing process ultimately results in poorly immunogenic cells remaining allowing for unchallenged tumour growth. In this review we look at the glycolysis pathway as a target for cancer treatments. We also examine the interplay between the glycolysis modulation and the immune response as an anti-cancer therapy.

AB - Increased glycolysis is the main source of energy supply in cancer cells that use this metabolic pathway for ATP generation. Altered energy metabolism is a biochemical fingerprint of cancer cells that represents one of the “hallmarks of cancer”. The immune system can prevent tumour growth by eliminating cancer cells but this editing process ultimately results in poorly immunogenic cells remaining allowing for unchallenged tumour growth. In this review we look at the glycolysis pathway as a target for cancer treatments. We also examine the interplay between the glycolysis modulation and the immune response as an anti-cancer therapy.

KW - Electroporation

KW - Glycolysis

KW - Glycolytic modulator

KW - Immune-metabolic interaction

UR - https://www.scopus.com/pages/publications/84977644949

U2 - 10.1016/j.bbcan.2016.06.005

DO - 10.1016/j.bbcan.2016.06.005

M3 - Review article

C2 - 27373814

AN - SCOPUS:84977644949

SN - 0304-419X

VL - 1866

SP - 87

EP - 105

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

IS - 1

ER -

Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

Abstract

UN SDGs

Keywords

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