GPCR Signaling: β-arrestins Kiss and Remember

Ravi Ranjan; Pragya Gupta; Arun K. Shukla

doi:10.1016/j.cub.2016.02.056

GPCR Signaling: β-arrestins Kiss and Remember

Ravi Ranjan
, Pragya Gupta
, Arun K. Shukla

Indian Institute of Technology Kanpur

Research output: Contribution to journal › Short survey › peer-review

Abstract

β-arrestin-dependent activation of the ERK MAP kinase downstream of GPCRs typically originates from internalized receptor-β-arrestin-ERK complexes. A new study now reports that β-arrestin 2 is sufficiently 'primed' after 'kissing' the β₁-adrenergic receptor to initiate ERK activation even in the absence of formation of the receptor-β-arrestin-ERK complex and receptor internalization.

Original language	English
Pages (from-to)	R285-R288
Journal	Current Biology
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.cub.2016.02.056
Publication status	Published - 4 Apr 2016
Externally published	Yes

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title = "GPCR Signaling: β-arrestins Kiss and Remember",

abstract = "β-arrestin-dependent activation of the ERK MAP kinase downstream of GPCRs typically originates from internalized receptor-β-arrestin-ERK complexes. A new study now reports that β-arrestin 2 is sufficiently 'primed' after 'kissing' the β1-adrenergic receptor to initiate ERK activation even in the absence of formation of the receptor-β-arrestin-ERK complex and receptor internalization.",

author = "Ravi Ranjan and Pragya Gupta and Shukla, \{Arun K.\}",

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AU - Ranjan, Ravi

AU - Gupta, Pragya

AU - Shukla, Arun K.

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Y1 - 2016/4/4

N2 - β-arrestin-dependent activation of the ERK MAP kinase downstream of GPCRs typically originates from internalized receptor-β-arrestin-ERK complexes. A new study now reports that β-arrestin 2 is sufficiently 'primed' after 'kissing' the β1-adrenergic receptor to initiate ERK activation even in the absence of formation of the receptor-β-arrestin-ERK complex and receptor internalization.

AB - β-arrestin-dependent activation of the ERK MAP kinase downstream of GPCRs typically originates from internalized receptor-β-arrestin-ERK complexes. A new study now reports that β-arrestin 2 is sufficiently 'primed' after 'kissing' the β1-adrenergic receptor to initiate ERK activation even in the absence of formation of the receptor-β-arrestin-ERK complex and receptor internalization.

UR - https://www.scopus.com/pages/publications/84962184037

U2 - 10.1016/j.cub.2016.02.056

DO - 10.1016/j.cub.2016.02.056

M3 - Short survey

C2 - 27046816

AN - SCOPUS:84962184037

SN - 0960-9822

VL - 26

SP - R285-R288

JO - Current Biology

JF - Current Biology

IS - 7

ER -

GPCR Signaling: β-arrestins Kiss and Remember

Abstract

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