Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia

A. Urwyler; T. Deufel; T. McCarthy; S. West

doi:10.1093/bja/86.2.283

Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia

A. Urwyler
, T. Deufel
, T. McCarthy
, S. West

School of Biochemistry and Cell Biology

Research output: Contribution to journal › Comment/Debate

Abstract

Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disease triggered by several anaesthetic agents. The in vitro muscle contracture test (IVCT) is the standard test to establish an individual's risk of susceptibility to MH. Clinical practitioners and geneticists of the European MH Group have agreed on the present guidelines for the detection of MH susceptibility using molecular genetic techniques and/or IVCT to predict the risk of MH.

Original language	English
Pages (from-to)	283-287
Number of pages	5
Journal	British Journal of Anaesthesia
Volume	86
Issue number	2
DOIs	https://doi.org/10.1093/bja/86.2.283
Publication status	Published - 2001

Keywords

Complications, malignant hyperthermia
Genetic factors, molecular genetics

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10.1093/bja/86.2.283

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title = "Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia",

abstract = "Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disease triggered by several anaesthetic agents. The in vitro muscle contracture test (IVCT) is the standard test to establish an individual's risk of susceptibility to MH. Clinical practitioners and geneticists of the European MH Group have agreed on the present guidelines for the detection of MH susceptibility using molecular genetic techniques and/or IVCT to predict the risk of MH.",

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AU - Deufel, T.

AU - McCarthy, T.

AU - West, S.

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AB - Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disease triggered by several anaesthetic agents. The in vitro muscle contracture test (IVCT) is the standard test to establish an individual's risk of susceptibility to MH. Clinical practitioners and geneticists of the European MH Group have agreed on the present guidelines for the detection of MH susceptibility using molecular genetic techniques and/or IVCT to predict the risk of MH.

KW - Complications, malignant hyperthermia

KW - Genetic factors, molecular genetics

UR - https://www.scopus.com/pages/publications/0035145133

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DO - 10.1093/bja/86.2.283

M3 - Comment/Debate

C2 - 11573677

AN - SCOPUS:0035145133

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EP - 287

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

IS - 2

ER -

Guidelines for molecular genetic detection of susceptibility to malignant hyperthermia

Abstract

Keywords

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