Gut Microbiome in Health and Disease: Emerging Diagnostic Opportunities

Aonghus Lavelle; Colin Hill

doi:10.1016/j.gtc.2019.02.003

Gut Microbiome in Health and Disease: Emerging Diagnostic Opportunities

Research output: Contribution to journal › Review article › peer-review

Abstract

The gut microbiome is fundamental to human health and development. Altered microbiomes have been associated with many diseases. However, variation between individuals, environmental effects, and a lack of standardization across studies makes differentiation between health and disease challenging. Large-scale population cohorts in different countries will be required to match disease subjects with healthy controls, whereas standardized, reproducible pipelines for analysis are required to compare findings between studies. Despite this, several conditions have already demonstrated great promise for developing microbiome-based biomarkers as well as providing a gateway into integrated personalized medicine.

Original language	English
Pages (from-to)	221-235
Number of pages	15
Journal	Gastroenterology Clinics of North America
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/j.gtc.2019.02.003
Publication status	Published - Jun 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomarkers
Cancer immunotherapy
Colorectal cancer
Fecal microbiota transplantation
Inflammatory bowel disease
Microbiome
Personalized medicine

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10.1016/j.gtc.2019.02.003

Cite this

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title = "Gut Microbiome in Health and Disease: Emerging Diagnostic Opportunities",

abstract = "The gut microbiome is fundamental to human health and development. Altered microbiomes have been associated with many diseases. However, variation between individuals, environmental effects, and a lack of standardization across studies makes differentiation between health and disease challenging. Large-scale population cohorts in different countries will be required to match disease subjects with healthy controls, whereas standardized, reproducible pipelines for analysis are required to compare findings between studies. Despite this, several conditions have already demonstrated great promise for developing microbiome-based biomarkers as well as providing a gateway into integrated personalized medicine.",

keywords = "Biomarkers, Cancer immunotherapy, Colorectal cancer, Fecal microbiota transplantation, Inflammatory bowel disease, Microbiome, Personalized medicine",

author = "Aonghus Lavelle and Colin Hill",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jun,

doi = "10.1016/j.gtc.2019.02.003",

language = "English",

volume = "48",

pages = "221--235",

journal = "Gastroenterology Clinics of North America",

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T1 - Gut Microbiome in Health and Disease

T2 - Emerging Diagnostic Opportunities

AU - Lavelle, Aonghus

AU - Hill, Colin

PY - 2019/6

Y1 - 2019/6

N2 - The gut microbiome is fundamental to human health and development. Altered microbiomes have been associated with many diseases. However, variation between individuals, environmental effects, and a lack of standardization across studies makes differentiation between health and disease challenging. Large-scale population cohorts in different countries will be required to match disease subjects with healthy controls, whereas standardized, reproducible pipelines for analysis are required to compare findings between studies. Despite this, several conditions have already demonstrated great promise for developing microbiome-based biomarkers as well as providing a gateway into integrated personalized medicine.

AB - The gut microbiome is fundamental to human health and development. Altered microbiomes have been associated with many diseases. However, variation between individuals, environmental effects, and a lack of standardization across studies makes differentiation between health and disease challenging. Large-scale population cohorts in different countries will be required to match disease subjects with healthy controls, whereas standardized, reproducible pipelines for analysis are required to compare findings between studies. Despite this, several conditions have already demonstrated great promise for developing microbiome-based biomarkers as well as providing a gateway into integrated personalized medicine.

KW - Biomarkers

KW - Cancer immunotherapy

KW - Colorectal cancer

KW - Fecal microbiota transplantation

KW - Inflammatory bowel disease

KW - Microbiome

KW - Personalized medicine

UR - https://www.scopus.com/pages/publications/85063761984

U2 - 10.1016/j.gtc.2019.02.003

DO - 10.1016/j.gtc.2019.02.003

M3 - Review article

C2 - 31046972

AN - SCOPUS:85063761984

SN - 0889-8553

VL - 48

SP - 221

EP - 235

JO - Gastroenterology Clinics of North America

JF - Gastroenterology Clinics of North America

IS - 2

ER -

Gut Microbiome in Health and Disease: Emerging Diagnostic Opportunities

Abstract

UN SDGs

Keywords

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