Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand

Anne T. Bruinvels; Bernhard Landwehrmeyer; Christian Waeber; JoséM M. Palacios; Daniel Hoyer

doi:10.1016/0014-2999(91)90257-Q

Homogeneous 5-HT_1D recognition sites in the human substantia nigra identified with a new iodinated radioligand

Anne T. Bruinvels
, Bernhard Landwehrmeyer
, Christian Waeber
, JoséM M. Palacios
, Daniel Hoyer

Preclinical Research

Research output: Contribution to journal › Article › peer-review

Abstract

The novel iodinated radioligand, scrotonin-5-O-carboxymcthyl-glycyl[¹²⁵I]tyrosinamide. was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of the 5-HT_1D site.

Original language	English
Pages (from-to)	89-91
Number of pages	3
Journal	European Journal of Pharmacology
Volume	202
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(91)90257-Q
Publication status	Published - 4 Sep 1991
Externally published	Yes

Keywords

5-HT sites
Scrotonin-5-O-carboxymethyl-glycyl[I]tyrosinamidc
Substantia nigra (human)

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10.1016/0014-2999(91)90257-Q

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title = "Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand",

abstract = "The novel iodinated radioligand, scrotonin-5-O-carboxymcthyl-glycyl[125I]tyrosinamide. was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of the 5-HT1D site.",

keywords = "5-HT sites, Scrotonin-5-O-carboxymethyl-glycyl[I]tyrosinamidc, Substantia nigra (human)",

author = "Bruinvels, \{Anne T.\} and Bernhard Landwehrmeyer and Christian Waeber and Palacios, \{Jos{\'e}M M.\} and Daniel Hoyer",

year = "1991",

month = sep,

day = "4",

doi = "10.1016/0014-2999(91)90257-Q",

language = "English",

volume = "202",

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journal = "European Journal of Pharmacology",

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TY - JOUR

T1 - Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand

AU - Bruinvels, Anne T.

AU - Landwehrmeyer, Bernhard

AU - Waeber, Christian

AU - Palacios, JoséM M.

AU - Hoyer, Daniel

PY - 1991/9/4

Y1 - 1991/9/4

N2 - The novel iodinated radioligand, scrotonin-5-O-carboxymcthyl-glycyl[125I]tyrosinamide. was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of the 5-HT1D site.

AB - The novel iodinated radioligand, scrotonin-5-O-carboxymcthyl-glycyl[125I]tyrosinamide. was used for binding studies with membranes of human substantia nigra. Evidence is provided for the existence in this tissue of a homogeneous population of recognition sites with the pharmacological profile of the 5-HT1D site.

KW - 5-HT sites

KW - Scrotonin-5-O-carboxymethyl-glycyl[I]tyrosinamidc

KW - Substantia nigra (human)

UR - https://www.scopus.com/pages/publications/0025918399

U2 - 10.1016/0014-2999(91)90257-Q

DO - 10.1016/0014-2999(91)90257-Q

M3 - Article

C2 - 1786802

AN - SCOPUS:0025918399

SN - 0014-2999

VL - 202

SP - 89

EP - 91

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Homogeneous 5-HT_1D recognition sites in the human substantia nigra identified with a new iodinated radioligand

Abstract

Keywords

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