TY - JOUR
T1 - Host-microbiome relationship in depression
T2 - can human induced pluripotent stem cells play a role in unravelling mechanisms?
AU - Rosell-Cardona, Cristina
AU - Cryan, John F.
AU - Clarke, Gerard
AU - Kittel-Schneider, Sarah
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Depression is highly prevalent, with many patients not responding to existing treatments. The gut microbiota plays a key role in its pathophysiology, offering new therapeutic avenues. Human-based research is essential to uncover mechanisms and validate new targets. Given CNS inaccessibility, human induced pluripotent stem cells (hiPSCs) offer an innovative model. This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.
AB - Depression is highly prevalent, with many patients not responding to existing treatments. The gut microbiota plays a key role in its pathophysiology, offering new therapeutic avenues. Human-based research is essential to uncover mechanisms and validate new targets. Given CNS inaccessibility, human induced pluripotent stem cells (hiPSCs) offer an innovative model. This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.
UR - https://www.scopus.com/pages/publications/105009899719
U2 - 10.1038/s41522-025-00749-z
DO - 10.1038/s41522-025-00749-z
M3 - Review article
C2 - 40595695
AN - SCOPUS:105009899719
SN - 2055-5008
VL - 11
JO - npj Biofilms and Microbiomes
JF - npj Biofilms and Microbiomes
IS - 1
M1 - 117
ER -