Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

Cristina Rosell-Cardona; John F. Cryan; Gerard Clarke; Sarah Kittel-Schneider

doi:10.1038/s41522-025-00749-z

Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

University of Würzburg

Research output: Contribution to journal › Review article › peer-review

Abstract

Depression is highly prevalent, with many patients not responding to existing treatments. The gut microbiota plays a key role in its pathophysiology, offering new therapeutic avenues. Human-based research is essential to uncover mechanisms and validate new targets. Given CNS inaccessibility, human induced pluripotent stem cells (hiPSCs) offer an innovative model. This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.

Original language	English
Article number	117
Journal	npj Biofilms and Microbiomes
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41522-025-00749-z
Publication status	Published - Dec 2025

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abstract = "Depression is highly prevalent, with many patients not responding to existing treatments. The gut microbiota plays a key role in its pathophysiology, offering new therapeutic avenues. Human-based research is essential to uncover mechanisms and validate new targets. Given CNS inaccessibility, human induced pluripotent stem cells (hiPSCs) offer an innovative model. This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.",

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AB - Depression is highly prevalent, with many patients not responding to existing treatments. The gut microbiota plays a key role in its pathophysiology, offering new therapeutic avenues. Human-based research is essential to uncover mechanisms and validate new targets. Given CNS inaccessibility, human induced pluripotent stem cells (hiPSCs) offer an innovative model. This review explores the emerging field of hiPSCs and their potential in advancing microbiota-gut-brain axis science and depression research.

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Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

Abstract

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