Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer

Alex Thompson; Hugh Manning; Mikkel Brydegaard; Sergio Coda; Gordon Kennedy; Rakesh Patalay; Ulrika Waitong-Braemming; Pieter De Beule; Mark Neil; Stefan Andersson-Engels; Yoshifumi Itoh; Niels Bendsøe; Christopher Dunsby; Katarina Svanberg; Paul M. French

doi:10.1117/12.875120

Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer

Alex Thompson
, Hugh Manning
, Mikkel Brydegaard
, Sergio Coda
, Gordon Kennedy
, Rakesh Patalay
, Ulrika Waitong-Braemming
, Pieter De Beule
, Mark Neil
, Stefan Andersson-Engels
, Yoshifumi Itoh
, Niels Bendsøe
, Christopher Dunsby
, Katarina Svanberg
, Paul M. French

Imperial College London
Lund University

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

Abstract

We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.

Original language	English
Title of host publication	Optical Biopsy IX
DOIs	https://doi.org/10.1117/12.875120
Publication status	Published - 2011
Externally published	Yes
Event	Optical Biopsy IX - San Francisco, CA, United States Duration: 24 Jan 2011 → 26 Jan 2011

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7895
ISSN (Print)	1605-7422

Conference

Conference	Optical Biopsy IX
Country/Territory	United States
City	San Francisco, CA
Period	24/01/11 → 26/01/11

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

diffuse reflectance
fibre probe
fluorescence
fluorescence lifetime
osteoarthritis
skin cancer
spectrometer

Access to Document

10.1117/12.875120

Cite this

Thompson, A., Manning, H., Brydegaard, M., Coda, S., Kennedy, G., Patalay, R., Waitong-Braemming, U., De Beule, P., Neil, M., Andersson-Engels, S., Itoh, Y., Bendsøe, N., Dunsby, C., Svanberg, K., & French, P. M. (2011). Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer. In Optical Biopsy IX Article 78950G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7895). https://doi.org/10.1117/12.875120

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title = "Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer",

abstract = "We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.",

keywords = "diffuse reflectance, fibre probe, fluorescence, fluorescence lifetime, osteoarthritis, skin cancer, spectrometer",

author = "Alex Thompson and Hugh Manning and Mikkel Brydegaard and Sergio Coda and Gordon Kennedy and Rakesh Patalay and Ulrika Waitong-Braemming and \{De Beule\}, Pieter and Mark Neil and Stefan Andersson-Engels and Yoshifumi Itoh and Niels Bends{\o}e and Christopher Dunsby and Katarina Svanberg and French, \{Paul M.\}",

year = "2011",

doi = "10.1117/12.875120",

language = "English",

isbn = "9780819484321",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Optical Biopsy IX",

note = "Optical Biopsy IX ; Conference date: 24-01-2011 Through 26-01-2011",

}

Thompson, A, Manning, H, Brydegaard, M, Coda, S, Kennedy, G, Patalay, R, Waitong-Braemming, U, De Beule, P, Neil, M, Andersson-Engels, S, Itoh, Y, Bendsøe, N, Dunsby, C, Svanberg, K & French, PM 2011, Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer. in Optical Biopsy IX., 78950G, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7895, Optical Biopsy IX, San Francisco, CA, United States, 24/01/11. https://doi.org/10.1117/12.875120

Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer. / Thompson, Alex; Manning, Hugh; Brydegaard, Mikkel et al.
Optical Biopsy IX. 2011. 78950G (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7895).

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

TY - GEN

T1 - Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer

AU - Thompson, Alex

AU - Manning, Hugh

AU - Brydegaard, Mikkel

AU - Coda, Sergio

AU - Kennedy, Gordon

AU - Patalay, Rakesh

AU - Waitong-Braemming, Ulrika

AU - De Beule, Pieter

AU - Neil, Mark

AU - Andersson-Engels, Stefan

AU - Itoh, Yoshifumi

AU - Bendsøe, Niels

AU - Dunsby, Christopher

AU - Svanberg, Katarina

AU - French, Paul M.

PY - 2011

Y1 - 2011

N2 - We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.

AB - We present the application of two fibre-optic-coupled time-resolved spectrofluorometers and a compact steady-state diffuse reflected light/fluorescence spectrometer to in vivo and ex vivo studies of skin cancer and osteoarthritis. In a clinical study of skin cancer, 27 lesions on 25 patients were investigated in vivo before surgical excision of the region measured. Preliminary analysis reveals a statistically significant decrease in the autofluorescence lifetime of basal cell carcinomas compared to neighbouring healthy tissue. A study of autofluorescence signals associated with the onset of osteoarthritis indicates autofluorescence lifetime changes associated with collagen degradation.

KW - diffuse reflectance

KW - fibre probe

KW - fluorescence

KW - fluorescence lifetime

KW - osteoarthritis

KW - skin cancer

KW - spectrometer

UR - https://www.scopus.com/pages/publications/79954510686

U2 - 10.1117/12.875120

DO - 10.1117/12.875120

M3 - Conference proceeding

AN - SCOPUS:79954510686

SN - 9780819484321

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Biopsy IX

T2 - Optical Biopsy IX

Y2 - 24 January 2011 through 26 January 2011

ER -

Hyperspectral fluorescence lifetime fibre probe spectroscopy for use in the study and diagnosis of osteoarthritis and skin cancer

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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