Immune privilege or inflammation? Insights into the Fas ligand enigma

Joe O'connell; Aileen Houston; Michael W. Bennett; Gerald C. O'sullivan; Fergus Shanahan

doi:10.1038/85395

Immune privilege or inflammation? Insights into the Fas ligand enigma

Joe O'connell
, Aileen Houston
, Michael W. Bennett
, Gerald C. O'sullivan
, Fergus Shanahan

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Fas ligand (FasL) has become an enigmatic molecule: some evidence indicates that it contributes to immune privilege in tissues and tumors, whereas other data demonstrates that FasL can elicit inflammation. New findings may begin to reconcile the paradoxical effects of FasL.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Nature Medicine
Volume	7
Issue number	3
DOIs	https://doi.org/10.1038/85395
Publication status	Published - 2001

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title = "Immune privilege or inflammation? Insights into the Fas ligand enigma",

abstract = "Fas ligand (FasL) has become an enigmatic molecule: some evidence indicates that it contributes to immune privilege in tissues and tumors, whereas other data demonstrates that FasL can elicit inflammation. New findings may begin to reconcile the paradoxical effects of FasL.",

author = "Joe O'connell and Aileen Houston and Bennett, \{Michael W.\} and O'sullivan, \{Gerald C.\} and Fergus Shanahan",

year = "2001",

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N2 - Fas ligand (FasL) has become an enigmatic molecule: some evidence indicates that it contributes to immune privilege in tissues and tumors, whereas other data demonstrates that FasL can elicit inflammation. New findings may begin to reconcile the paradoxical effects of FasL.

AB - Fas ligand (FasL) has become an enigmatic molecule: some evidence indicates that it contributes to immune privilege in tissues and tumors, whereas other data demonstrates that FasL can elicit inflammation. New findings may begin to reconcile the paradoxical effects of FasL.

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U2 - 10.1038/85395

DO - 10.1038/85395

M3 - Review article

C2 - 11231613

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JO - Nature Medicine

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Immune privilege or inflammation? Insights into the Fas ligand enigma

Abstract

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