Immune regulation by histamine and histamine-secreting bacteria

Weronika Barcik; Marcin Wawrzyniak; Cezmi A. Akdis; Liam O'Mahony

doi:10.1016/j.coi.2017.08.011

Immune regulation by histamine and histamine-secreting bacteria

Weronika Barcik
, Marcin Wawrzyniak
, Cezmi A. Akdis
, Liam O'Mahony

University of Zurich
Christine Kühne – Center for Allergy Research and Education (CK-CARE)

Research output: Contribution to journal › Review article › peer-review

Abstract

Histamine is a biogenic amine with extensive effects on many immune cell types. Histamine and its four receptors (H1R–H4R) represent a complex system of immunoregulation with distinct effects dependent on receptor subtypes and their differential expression. In addition to mammalian cells, bacteria can also secrete histamine and the influence of microbiota-derived histamine on host immunological processes is only beginning to be described. However, it is clear that histamine-secreting microbes are present within the human gut microbiota and their levels are increased in asthma patients. Additional studies are required to fully understand the complex regulatory interactions between histamine and the host immune response to everyday microbial and environmental challenges.

Original language	English
Pages (from-to)	108-113
Number of pages	6
Journal	Current Opinion in Immunology
Volume	48
DOIs	https://doi.org/10.1016/j.coi.2017.08.011
Publication status	Published - Oct 2017
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1016/j.coi.2017.08.011

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title = "Immune regulation by histamine and histamine-secreting bacteria",

abstract = "Histamine is a biogenic amine with extensive effects on many immune cell types. Histamine and its four receptors (H1R–H4R) represent a complex system of immunoregulation with distinct effects dependent on receptor subtypes and their differential expression. In addition to mammalian cells, bacteria can also secrete histamine and the influence of microbiota-derived histamine on host immunological processes is only beginning to be described. However, it is clear that histamine-secreting microbes are present within the human gut microbiota and their levels are increased in asthma patients. Additional studies are required to fully understand the complex regulatory interactions between histamine and the host immune response to everyday microbial and environmental challenges.",

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doi = "10.1016/j.coi.2017.08.011",

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AU - Barcik, Weronika

AU - Wawrzyniak, Marcin

AU - Akdis, Cezmi A.

AU - O'Mahony, Liam

PY - 2017/10

Y1 - 2017/10

N2 - Histamine is a biogenic amine with extensive effects on many immune cell types. Histamine and its four receptors (H1R–H4R) represent a complex system of immunoregulation with distinct effects dependent on receptor subtypes and their differential expression. In addition to mammalian cells, bacteria can also secrete histamine and the influence of microbiota-derived histamine on host immunological processes is only beginning to be described. However, it is clear that histamine-secreting microbes are present within the human gut microbiota and their levels are increased in asthma patients. Additional studies are required to fully understand the complex regulatory interactions between histamine and the host immune response to everyday microbial and environmental challenges.

AB - Histamine is a biogenic amine with extensive effects on many immune cell types. Histamine and its four receptors (H1R–H4R) represent a complex system of immunoregulation with distinct effects dependent on receptor subtypes and their differential expression. In addition to mammalian cells, bacteria can also secrete histamine and the influence of microbiota-derived histamine on host immunological processes is only beginning to be described. However, it is clear that histamine-secreting microbes are present within the human gut microbiota and their levels are increased in asthma patients. Additional studies are required to fully understand the complex regulatory interactions between histamine and the host immune response to everyday microbial and environmental challenges.

UR - https://www.scopus.com/pages/publications/85029438900

U2 - 10.1016/j.coi.2017.08.011

DO - 10.1016/j.coi.2017.08.011

M3 - Review article

C2 - 28923468

AN - SCOPUS:85029438900

SN - 0952-7915

VL - 48

SP - 108

EP - 113

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -

Immune regulation by histamine and histamine-secreting bacteria

Abstract

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