TY - JOUR
T1 - Impact of gut fungal and bacterial communities on the outcome of allogeneic hematopoietic cell transplantation
AU - Malard, Florent
AU - Lavelle, Aonghus
AU - Battipaglia, Giorgia
AU - Gaugler, Béatrice
AU - Dulery, Rémy
AU - Brissot, Eolia
AU - Mediavilla, Clémence
AU - Jegou, Sarah
AU - Rolhion, Nathalie
AU - Ledraa, Tounes
AU - Mohty, Razan
AU - Sokol, Harry
AU - Mohty, Mohamad
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Society for Mucosal Immunology.
PY - 2021/9
Y1 - 2021/9
N2 - Patients receiving allogeneic hematopoietic cell transplantation (alloHCT) were previously shown to display a bacterial gut dysbiosis; however, limited data are available regarding the role of fungal microbiota in these patients. We evaluated the bacterial and fungal composition of the fecal microbiota at day 0 of alloHCT. Higher bacterial diversity was associated with an improved overall survival (OS) and disease-free survival (DFS). While fungal diversity had no impact on patient outcomes, we observed that high versus low relative abundance of Candida albicans in alloHCT patients at day 0 was associated with a significantly lower OS, DFS and graft-versus-host-free, relapse-free survival (GRFS) (p = 0.0008, p = 0.0064 and p = 0.026, respectively). While these results are limited by low patient numbers and low fungal read counts in some samples, they suggest a potentially important role for C albicans in alloHCT.
AB - Patients receiving allogeneic hematopoietic cell transplantation (alloHCT) were previously shown to display a bacterial gut dysbiosis; however, limited data are available regarding the role of fungal microbiota in these patients. We evaluated the bacterial and fungal composition of the fecal microbiota at day 0 of alloHCT. Higher bacterial diversity was associated with an improved overall survival (OS) and disease-free survival (DFS). While fungal diversity had no impact on patient outcomes, we observed that high versus low relative abundance of Candida albicans in alloHCT patients at day 0 was associated with a significantly lower OS, DFS and graft-versus-host-free, relapse-free survival (GRFS) (p = 0.0008, p = 0.0064 and p = 0.026, respectively). While these results are limited by low patient numbers and low fungal read counts in some samples, they suggest a potentially important role for C albicans in alloHCT.
UR - https://www.scopus.com/pages/publications/85110776229
U2 - 10.1038/s41385-021-00429-z
DO - 10.1038/s41385-021-00429-z
M3 - Article
C2 - 34282272
AN - SCOPUS:85110776229
SN - 1933-0219
VL - 14
SP - 1127
EP - 1132
JO - Mucosal Immunology
JF - Mucosal Immunology
IS - 5
ER -