Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts

S. Santos; E. Voerman; P. Amiano; H. Barros; L. J. Beilin; A. Bergström; M. A. Charles; L. Chatzi; C. Chevrier; G. P. Chrousos; E. Corpeleijn; O. Costa; N. Costet; S. Crozier; G. Devereux; M. Doyon; M. Eggesbø; M. P. Fantini; S. Farchi; F. Forastiere; V. Georgiu; K. M. Godfrey; D. Gori; V. Grote; W. Hanke; I. Hertz-Picciotto; B. Heude; M. F. Hivert; D. Hryhorczuk; R. C. Huang; H. Inskip; A. M. Karvonen; L. C. Kenny; B. Koletzko; L. K. Küpers; H. Lagström; I. Lehmann; P. Magnus; R. Majewska; J. Mäkelä; Y. Manios; F. M. McAuliffe; S. W. McDonald; J. Mehegan; E. Melén; M. Mommers; C. S. Morgen; G. Moschonis; D. Murray; C. Ní Chaoimh; E. A. Nohr; A. M. Nybo Andersen; E. Oken; A. J.J.M. Oostvogels; A. Pac; E. Papadopoulou; J. Pekkanen; C. Pizzi; K. Polanska; D. Porta; L. Richiardi; S. L. Rifas-Shiman; N. Roeleveld; L. Ronfani; A. C. Santos; M. Standl; H. Stigum; C. Stoltenberg; E. Thiering; C. Thijs; M. Torrent; S. C. Tough; T. Trnovec; S. Turner; M. M.H.J. van Gelder; L. van Rossem; A. von Berg; M. Vrijheid; T. G.M. Vrijkotte; J. West; A. H. Wijga; J. Wright; O. Zvinchuk; T. I.A. Sørensen; D. A. Lawlor; R. Gaillard; V. W.V. Jaddoe

doi:10.1111/1471-0528.15661

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts

S. Santos
, E. Voerman
, P. Amiano
, H. Barros
, L. J. Beilin
, A. Bergström
, M. A. Charles
, L. Chatzi
, C. Chevrier
, G. P. Chrousos
, E. Corpeleijn
, O. Costa
, N. Costet
, S. Crozier
, G. Devereux
, M. Doyon
, M. Eggesbø
, M. P. Fantini
, S. Farchi
, F. Forastiere

V. Georgiu, K. M. Godfrey, D. Gori, V. Grote, W. Hanke, I. Hertz-Picciotto, B. Heude, M. F. Hivert, D. Hryhorczuk, R. C. Huang, H. Inskip, A. M. Karvonen, L. C. Kenny, B. Koletzko, L. K. Küpers, H. Lagström, I. Lehmann, P. Magnus, R. Majewska, J. Mäkelä, Y. Manios, F. M. McAuliffe, S. W. McDonald, J. Mehegan, E. Melén, M. Mommers, C. S. Morgen, G. Moschonis, D. Murray, C. Ní Chaoimh, E. A. Nohr, A. M. Nybo Andersen, E. Oken, A. J.J.M. Oostvogels, A. Pac, E. Papadopoulou, J. Pekkanen, C. Pizzi, K. Polanska, D. Porta, L. Richiardi, S. L. Rifas-Shiman, N. Roeleveld, L. Ronfani, A. C. Santos, M. Standl, H. Stigum, C. Stoltenberg, E. Thiering, C. Thijs, M. Torrent, S. C. Tough, T. Trnovec, S. Turner, M. M.H.J. van Gelder, L. van Rossem, A. von Berg, M. Vrijheid, T. G.M. Vrijkotte, J. West, A. H. Wijga, J. Wright, O. Zvinchuk, T. I.A. Sørensen, D. A. Lawlor, R. Gaillard, V. W.V. Jaddoe

Erasmus University Rotterdam
Public Health Division of Gipuzkoa
Instituto de Investigación Sanitaria Biodonostia
Biomedical Research Networking Center in Epidemiology and Public Health (CiberESP)
University of Porto
Royal Perth Hospital
Karolinska Institutet
Stockholm County Council
Institut national de la santé et de la recherche médicale
Université Paris Cité
University of Southern California
University of Crete
Maastricht University
Irset–Research Institute for Environmental and Occupational Health
National and Kapodistrian University of Athens
University of Groningen
University of Valencia
MRC Lifecourse Epidemiology Unit
Liverpool School of Tropical Medicine
Centre de Recherche du Centre Hospitalier de l'Universite de Sherbrooke
Norwegian Institute of Public Health
University of Bologna
Department of Epidemiology Lazio Regional Health Service
University Hospital Southampton NHS Foundation Trust
Ludwig Maximilian University of Munich
Nofer Institute of Occupational Medicine
University of California at Davis
Harvard University
Massachusetts General Hospital
University of Illinois at Chicago
University of Western Australia
National Institute for Health and Welfare
Cork University Maternity Hospital
University of Bristol
Wageningen University & Research
University of Turku
Helmholtz Centre for Environmental Research
Jagiellonian University Medical College
Harokopio University
University College Dublin
University of Calgary
University of Southern Denmark
University of Copenhagen
La Trobe University
University College Cork
Amsterdam University Medical Centers
University of Helsinki
University of Turin
Radboud University Nijmegen
IRCCS Ospedale Infantile Burlo Garofolo - Trieste
Helmholtz Zentrum München - German Research Center for Environmental Health
University of Bergen
IB-SALUT
Slovak Medical University
NHS Grampian
Utrecht University
Marien-Hospital Wesel
Barcelona Institute for Global Health
Pompeu Fabra University
Bradford Teaching Hospitals NHS Foundation Trust
National Institute of Public Health and the Environment
Institute of Pediatrics, Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design: Individual participant data meta-analysis of 39 cohorts. Setting: Europe, North America, and Oceania. Population: 265 270 births. Methods: Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures: Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results: Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions: Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. Tweetable abstract: Promoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.

Original language	English
Pages (from-to)	984-995
Number of pages	12
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	126
Issue number	8
DOIs	https://doi.org/10.1111/1471-0528.15661
Publication status	Published - Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Birthweight
body mass index
pregnancy complications
preterm birth
weight gain

Access to Document

10.1111/1471-0528.15661

https://hdl.handle.net/10468/7773Licence: CC BY-NC-ND

Cite this

Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergström, A., Charles, M. A., Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbø, M., Fantini, M. P., Farchi, S., ... Jaddoe, V. W. V. (2019). Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts. BJOG: An International Journal of Obstetrics and Gynaecology, 126(8), 984-995. https://doi.org/10.1111/1471-0528.15661

@article{df2541d947154d78b086c8bd131467ac,

title = "Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts",

abstract = "Objective: To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design: Individual participant data meta-analysis of 39 cohorts. Setting: Europe, North America, and Oceania. Population: 265 270 births. Methods: Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures: Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results: Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95\% CI 2.31– 2.74). We estimated that 23.9\% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6\% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions: Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. Tweetable abstract: Promoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.",

keywords = "Birthweight, body mass index, pregnancy complications, preterm birth, weight gain",

author = "S. Santos and E. Voerman and P. Amiano and H. Barros and Beilin, \{L. J.\} and A. Bergstr{\"o}m and Charles, \{M. A.\} and L. Chatzi and C. Chevrier and Chrousos, \{G. P.\} and E. Corpeleijn and O. Costa and N. Costet and S. Crozier and G. Devereux and M. Doyon and M. Eggesb{\o} and Fantini, \{M. P.\} and S. Farchi and F. Forastiere and V. Georgiu and Godfrey, \{K. M.\} and D. Gori and V. Grote and W. Hanke and I. Hertz-Picciotto and B. Heude and Hivert, \{M. F.\} and D. Hryhorczuk and Huang, \{R. C.\} and H. Inskip and Karvonen, \{A. M.\} and Kenny, \{L. C.\} and B. Koletzko and K{\"u}pers, \{L. K.\} and H. Lagstr{\"o}m and I. Lehmann and P. Magnus and R. Majewska and J. M{\"a}kel{\"a} and Y. Manios and McAuliffe, \{F. M.\} and McDonald, \{S. W.\} and J. Mehegan and E. Mel{\'e}n and M. Mommers and Morgen, \{C. S.\} and G. Moschonis and D. Murray and \{N{\'i} Chaoimh\}, C. and Nohr, \{E. A.\} and \{Nybo Andersen\}, \{A. M.\} and E. Oken and Oostvogels, \{A. J.J.M.\} and A. Pac and E. Papadopoulou and J. Pekkanen and C. Pizzi and K. Polanska and D. Porta and L. Richiardi and Rifas-Shiman, \{S. L.\} and N. Roeleveld and L. Ronfani and Santos, \{A. C.\} and M. Standl and H. Stigum and C. Stoltenberg and E. Thiering and C. Thijs and M. Torrent and Tough, \{S. C.\} and T. Trnovec and S. Turner and \{van Gelder\}, \{M. M.H.J.\} and \{van Rossem\}, L. and \{von Berg\}, A. and M. Vrijheid and Vrijkotte, \{T. G.M.\} and J. West and Wijga, \{A. H.\} and J. Wright and O. Zvinchuk and S{\o}rensen, \{T. I.A.\} and Lawlor, \{D. A.\} and R. Gaillard and Jaddoe, \{V. W.V.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Royal College of Obstetricians and Gynaecologists",

year = "2019",

month = jul,

doi = "10.1111/1471-0528.15661",

language = "English",

volume = "126",

pages = "984--995",

journal = "BJOG: An International Journal of Obstetrics and Gynaecology",

issn = "1470-0328",

publisher = "John Wiley and Sons Inc",

number = "8",

}

Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, LJ, Bergström, A, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbø, M, Fantini, MP, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, MF, Hryhorczuk, D, Huang, RC, Inskip, H, Karvonen, AM, Kenny, LC, Koletzko, B, Küpers, LK, Lagström, H, Lehmann, I, Magnus, P, Majewska, R, Mäkelä, J, Manios, Y, McAuliffe, FM, McDonald, SW, Mehegan, J, Melén, E, Mommers, M, Morgen, CS, Moschonis, G, Murray, D, Ní Chaoimh, C, Nohr, EA, Nybo Andersen, AM, Oken, E, Oostvogels, AJJM, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Ronfani, L, Santos, AC, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Turner, S, van Gelder, MMHJ, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, TGM, West, J, Wijga, AH, Wright, J, Zvinchuk, O, Sørensen, TIA, Lawlor, DA, Gaillard, R & Jaddoe, VWV 2019, 'Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 126, no. 8, pp. 984-995. https://doi.org/10.1111/1471-0528.15661

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts. / Santos, S.; Voerman, E.; Amiano, P. et al.
In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 126, No. 8, 07.2019, p. 984-995.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Impact of maternal body mass index and gestational weight gain on pregnancy complications

T2 - an individual participant data meta-analysis of European, North American and Australian cohorts

AU - Santos, S.

AU - Voerman, E.

AU - Amiano, P.

AU - Barros, H.

AU - Beilin, L. J.

AU - Bergström, A.

AU - Charles, M. A.

AU - Chatzi, L.

AU - Chevrier, C.

AU - Chrousos, G. P.

AU - Corpeleijn, E.

AU - Costa, O.

AU - Costet, N.

AU - Crozier, S.

AU - Devereux, G.

AU - Doyon, M.

AU - Eggesbø, M.

AU - Fantini, M. P.

AU - Farchi, S.

AU - Forastiere, F.

AU - Georgiu, V.

AU - Godfrey, K. M.

AU - Gori, D.

AU - Grote, V.

AU - Hanke, W.

AU - Hertz-Picciotto, I.

AU - Heude, B.

AU - Hivert, M. F.

AU - Hryhorczuk, D.

AU - Huang, R. C.

AU - Inskip, H.

AU - Karvonen, A. M.

AU - Kenny, L. C.

AU - Koletzko, B.

AU - Küpers, L. K.

AU - Lagström, H.

AU - Lehmann, I.

AU - Magnus, P.

AU - Majewska, R.

AU - Mäkelä, J.

AU - Manios, Y.

AU - McAuliffe, F. M.

AU - McDonald, S. W.

AU - Mehegan, J.

AU - Melén, E.

AU - Mommers, M.

AU - Morgen, C. S.

AU - Moschonis, G.

AU - Murray, D.

AU - Ní Chaoimh, C.

AU - Nohr, E. A.

AU - Nybo Andersen, A. M.

AU - Oken, E.

AU - Oostvogels, A. J.J.M.

AU - Pac, A.

AU - Papadopoulou, E.

AU - Pekkanen, J.

AU - Pizzi, C.

AU - Polanska, K.

AU - Porta, D.

AU - Richiardi, L.

AU - Rifas-Shiman, S. L.

AU - Roeleveld, N.

AU - Ronfani, L.

AU - Santos, A. C.

AU - Standl, M.

AU - Stigum, H.

AU - Stoltenberg, C.

AU - Thiering, E.

AU - Thijs, C.

AU - Torrent, M.

AU - Tough, S. C.

AU - Trnovec, T.

AU - Turner, S.

AU - van Gelder, M. M.H.J.

AU - van Rossem, L.

AU - von Berg, A.

AU - Vrijheid, M.

AU - Vrijkotte, T. G.M.

AU - West, J.

AU - Wijga, A. H.

AU - Wright, J.

AU - Zvinchuk, O.

AU - Sørensen, T. I.A.

AU - Lawlor, D. A.

AU - Gaillard, R.

AU - Jaddoe, V. W.V.

PY - 2019/7

Y1 - 2019/7

N2 - Objective: To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design: Individual participant data meta-analysis of 39 cohorts. Setting: Europe, North America, and Oceania. Population: 265 270 births. Methods: Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures: Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results: Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions: Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. Tweetable abstract: Promoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.

AB - Objective: To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design: Individual participant data meta-analysis of 39 cohorts. Setting: Europe, North America, and Oceania. Population: 265 270 births. Methods: Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used. Main outcome measures: Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth. Results: Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain. Conclusions: Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. Tweetable abstract: Promoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.

KW - Birthweight

KW - body mass index

KW - pregnancy complications

KW - preterm birth

KW - weight gain

UR - https://www.scopus.com/pages/publications/85065645885

U2 - 10.1111/1471-0528.15661

DO - 10.1111/1471-0528.15661

M3 - Article

C2 - 30786138

AN - SCOPUS:85065645885

SN - 1470-0328

VL - 126

SP - 984

EP - 995

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

IS - 8

ER -

Santos S, Voerman E, Amiano P, Barros H, Beilin LJ, Bergström A et al. Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts. BJOG: An International Journal of Obstetrics and Gynaecology. 2019 Jul;126(8):984-995. doi: 10.1111/1471-0528.15661

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts

Abstract

UN SDGs

Keywords

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