TY - JOUR
T1 - In vitro digestion of infant formula model systems
T2 - Influence of casein to whey protein ratio
AU - Phosanam, Arissara
AU - Chandrapala, Jayani
AU - Huppertz, Thom
AU - Adhikari, Benu
AU - Zisu, Bogdan
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/6
Y1 - 2021/6
N2 - The influence of casein-to-whey protein ratio (C:WP; 40:60, 60:40, 80:20) on the digestibility of infant formula powder was studied using an in vitro digestion model. With increasing C:WP, more extensive coagulation in samples was observed through particle size and confocal microscopy analyses. Coagulum particles consisted of a protein matrix in which emulsion droplets were embedded. The more extensive coagulation also led to significant (p < 0.05) reductions in protein and fat digestion during gastric and intestinal stages of digestion. These reductions can be attributed to reduced accessibility of digestive enzymes to their respective substrates. Gastric coagulation of the caseins was less extensive and digestion of protein and lipid was highest at C:WP of 40:60, which closely resembled human milk. The strong effects of C:WP on the digestion of infant formula further highlight the importance of the gastric coagulation process to ensure efficient digestion of protein and fat.
AB - The influence of casein-to-whey protein ratio (C:WP; 40:60, 60:40, 80:20) on the digestibility of infant formula powder was studied using an in vitro digestion model. With increasing C:WP, more extensive coagulation in samples was observed through particle size and confocal microscopy analyses. Coagulum particles consisted of a protein matrix in which emulsion droplets were embedded. The more extensive coagulation also led to significant (p < 0.05) reductions in protein and fat digestion during gastric and intestinal stages of digestion. These reductions can be attributed to reduced accessibility of digestive enzymes to their respective substrates. Gastric coagulation of the caseins was less extensive and digestion of protein and lipid was highest at C:WP of 40:60, which closely resembled human milk. The strong effects of C:WP on the digestion of infant formula further highlight the importance of the gastric coagulation process to ensure efficient digestion of protein and fat.
UR - https://www.scopus.com/pages/publications/85101477418
U2 - 10.1016/j.idairyj.2021.105008
DO - 10.1016/j.idairyj.2021.105008
M3 - Article
AN - SCOPUS:85101477418
SN - 0958-6946
VL - 117
JO - International Dairy Journal
JF - International Dairy Journal
M1 - 105008
ER -