In Vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin

Ingrid Wang; Stefan Andersson-Engels; Ingrid Idvall; Christian Ingvar; Katarina Svanberg

doi:10.1117/12.176006

In Vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin

Ingrid Wang
, Stefan Andersson-Engels
, Ingrid Idvall
, Christian Ingvar
, Katarina Svanberg

Lund University

Research output: Contribution to journal › Article › peer-review

Abstract

A study in order to investigate the uptake of porphyrins in neoplasias in the female breast tissue and to evaluate the potential of fluorescence diagnostics for tumor demarcation was performed. Six women with positive mammography and cytological biopsies took part in the study. The patients were given Photofrin intravenously in a low dose of 0.35 mg/kg b.w. 24 hours before the planned surgical procedure. Immediately after surgery the pathological specimen were investigated with fluorescence spectroscopy following 405 nm laser excitation. Afterwards the investigated tissue sample was taken for histological preparation. The spectroscopic results were correlated with the histopathological diagnoses. The study shows a good demarcation between invasive or in situ cancerous tissue and the surrounding breast tissue, based on fluorescence data.

Original language	English
Pages (from-to)	139-146
Number of pages	8
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	2135
DOIs	https://doi.org/10.1117/12.176006
Publication status	Published - 19 May 1994
Externally published	Yes
Event	Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases 1994 - Los Angeles, United States Duration: 23 Jan 1994 → 29 Jan 1994

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SDG 3 Good Health and Well-being

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10.1117/12.176006

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title = "In Vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin",

abstract = "A study in order to investigate the uptake of porphyrins in neoplasias in the female breast tissue and to evaluate the potential of fluorescence diagnostics for tumor demarcation was performed. Six women with positive mammography and cytological biopsies took part in the study. The patients were given Photofrin intravenously in a low dose of 0.35 mg/kg b.w. 24 hours before the planned surgical procedure. Immediately after surgery the pathological specimen were investigated with fluorescence spectroscopy following 405 nm laser excitation. Afterwards the investigated tissue sample was taken for histological preparation. The spectroscopic results were correlated with the histopathological diagnoses. The study shows a good demarcation between invasive or in situ cancerous tissue and the surrounding breast tissue, based on fluorescence data.",

author = "Ingrid Wang and Stefan Andersson-Engels and Ingrid Idvall and Christian Ingvar and Katarina Svanberg",

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doi = "10.1117/12.176006",

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T1 - In Vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin

AU - Wang, Ingrid

AU - Andersson-Engels, Stefan

AU - Idvall, Ingrid

AU - Ingvar, Christian

AU - Svanberg, Katarina

PY - 1994/5/19

Y1 - 1994/5/19

N2 - A study in order to investigate the uptake of porphyrins in neoplasias in the female breast tissue and to evaluate the potential of fluorescence diagnostics for tumor demarcation was performed. Six women with positive mammography and cytological biopsies took part in the study. The patients were given Photofrin intravenously in a low dose of 0.35 mg/kg b.w. 24 hours before the planned surgical procedure. Immediately after surgery the pathological specimen were investigated with fluorescence spectroscopy following 405 nm laser excitation. Afterwards the investigated tissue sample was taken for histological preparation. The spectroscopic results were correlated with the histopathological diagnoses. The study shows a good demarcation between invasive or in situ cancerous tissue and the surrounding breast tissue, based on fluorescence data.

AB - A study in order to investigate the uptake of porphyrins in neoplasias in the female breast tissue and to evaluate the potential of fluorescence diagnostics for tumor demarcation was performed. Six women with positive mammography and cytological biopsies took part in the study. The patients were given Photofrin intravenously in a low dose of 0.35 mg/kg b.w. 24 hours before the planned surgical procedure. Immediately after surgery the pathological specimen were investigated with fluorescence spectroscopy following 405 nm laser excitation. Afterwards the investigated tissue sample was taken for histological preparation. The spectroscopic results were correlated with the histopathological diagnoses. The study shows a good demarcation between invasive or in situ cancerous tissue and the surrounding breast tissue, based on fluorescence data.

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DO - 10.1117/12.176006

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JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases 1994

Y2 - 23 January 1994 through 29 January 1994

ER -

In Vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin

Abstract

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