@inbook{f63c0263a6d44d1cae041c00e7f404af,
title = "In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke",
abstract = "Neonatal stroke presents with features of encephalopathy and can result in significant morbidity and mortality. We investigated the cerebral metabolic and haemodynamic changes following neonatal stroke in a term infant at 24 h of life. Changes in oxidation state of cytochrome-c-oxidase (oxCCO) concentration were monitored along with changes in oxy- and deoxy- haemoglobin using a new broadband near-infrared spectroscopy (NIRS) system. Repeated transient changes in cerebral haemodynamics and metabolism were noted over a 3-h study period with decrease in oxyhaemoglobin (HbO2), deoxy haemoglobin (HHb) and oxCCO in both cerebral hemispheres without significant changes in systemic observations. A clear asymmetry was noted in the degree of change between the two cerebral hemispheres. Changes in cerebral oxygenation (measured as HbDiff=HbO2 -HHb) and cerebral metabolism (measured as oxCCO) were highly coupled on the injured side of the brain.",
keywords = "Broadband nirs, Cerebral hemodynamics, Cytochrome c oxidase, Mitochondrial metabolism, Neonatal stroke",
author = "Subhabrata Mitra and Gemma Bale and Judith Meek and Sean Mathieson and Cristina Uria and Giles Kendall and Robertson, \{Nicola J.\} and Ilias Tachtsidis",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2016.; 42nd Annual Meeting of International Society on Oxygen Transport to Tissue ; Conference date: 28-06-2014 Through 03-07-2014",
year = "2016",
doi = "10.1007/978-1-4939-3023-4\_62",
language = "English",
isbn = "9781493930227",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "493--499",
editor = "Elwell, \{Clare E.\} and Leung, \{Terence S.\} and Harrison, \{David K.\}",
booktitle = "Oxygen Transport to Tissue XXXVII",
}
