In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke

Subhabrata Mitra; Gemma Bale; Judith Meek; Sean Mathieson; Cristina Uria; Giles Kendall; Nicola J. Robertson; Ilias Tachtsidis

doi:10.1007/978-1-4939-3023-4_62

In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke

Subhabrata Mitra
, Gemma Bale
, Judith Meek
, Sean Mathieson
, Cristina Uria
, Giles Kendall
, Nicola J. Robertson
, Ilias Tachtsidis

University College London

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

Abstract

Neonatal stroke presents with features of encephalopathy and can result in significant morbidity and mortality. We investigated the cerebral metabolic and haemodynamic changes following neonatal stroke in a term infant at 24 h of life. Changes in oxidation state of cytochrome-c-oxidase (oxCCO) concentration were monitored along with changes in oxy- and deoxy- haemoglobin using a new broadband near-infrared spectroscopy (NIRS) system. Repeated transient changes in cerebral haemodynamics and metabolism were noted over a 3-h study period with decrease in oxyhaemoglobin (HbO₂), deoxy haemoglobin (HHb) and oxCCO in both cerebral hemispheres without significant changes in systemic observations. A clear asymmetry was noted in the degree of change between the two cerebral hemispheres. Changes in cerebral oxygenation (measured as HbDiff=HbO2 -HHb) and cerebral metabolism (measured as oxCCO) were highly coupled on the injured side of the brain.

Original language	English
Title of host publication	Oxygen Transport to Tissue XXXVII
Editors	Clare E. Elwell, Terence S. Leung, David K. Harrison
Publisher	Springer New York LLC
Pages	493-499
Number of pages	7
ISBN (Print)	9781493930227
DOIs	https://doi.org/10.1007/978-1-4939-3023-4_62
Publication status	Published - 2016
Externally published	Yes
Event	42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom Duration: 28 Jun 2014 → 3 Jul 2014

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	876
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Conference

Conference	42nd Annual Meeting of International Society on Oxygen Transport to Tissue
Country/Territory	United Kingdom
City	London
Period	28/06/14 → 3/07/14

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Broadband nirs
Cerebral hemodynamics
Cytochrome c oxidase
Mitochondrial metabolism
Neonatal stroke

Access to Document

10.1007/978-1-4939-3023-4_62

Cite this

Mitra, S., Bale, G., Meek, J., Mathieson, S., Uria, C., Kendall, G., Robertson, N. J., & Tachtsidis, I. (2016). In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke. In C. E. Elwell, T. S. Leung, & D. K. Harrison (Eds.), Oxygen Transport to Tissue XXXVII (pp. 493-499). (Advances in Experimental Medicine and Biology; Vol. 876). Springer New York LLC. https://doi.org/10.1007/978-1-4939-3023-4_62

Mitra, Subhabrata ; Bale, Gemma ; Meek, Judith et al. / In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke. Oxygen Transport to Tissue XXXVII. editor / Clare E. Elwell ; Terence S. Leung ; David K. Harrison. Springer New York LLC, 2016. pp. 493-499 (Advances in Experimental Medicine and Biology).

@inproceedings{f63c0263a6d44d1cae041c00e7f404af,

title = "In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke",

abstract = "Neonatal stroke presents with features of encephalopathy and can result in significant morbidity and mortality. We investigated the cerebral metabolic and haemodynamic changes following neonatal stroke in a term infant at 24 h of life. Changes in oxidation state of cytochrome-c-oxidase (oxCCO) concentration were monitored along with changes in oxy- and deoxy- haemoglobin using a new broadband near-infrared spectroscopy (NIRS) system. Repeated transient changes in cerebral haemodynamics and metabolism were noted over a 3-h study period with decrease in oxyhaemoglobin (HbO2), deoxy haemoglobin (HHb) and oxCCO in both cerebral hemispheres without significant changes in systemic observations. A clear asymmetry was noted in the degree of change between the two cerebral hemispheres. Changes in cerebral oxygenation (measured as HbDiff=HbO2 -HHb) and cerebral metabolism (measured as oxCCO) were highly coupled on the injured side of the brain.",

keywords = "Broadband nirs, Cerebral hemodynamics, Cytochrome c oxidase, Mitochondrial metabolism, Neonatal stroke",

author = "Subhabrata Mitra and Gemma Bale and Judith Meek and Sean Mathieson and Cristina Uria and Giles Kendall and Robertson, \{Nicola J.\} and Ilias Tachtsidis",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2016.; 42nd Annual Meeting of International Society on Oxygen Transport to Tissue ; Conference date: 28-06-2014 Through 03-07-2014",

year = "2016",

doi = "10.1007/978-1-4939-3023-4\_62",

language = "English",

isbn = "9781493930227",

series = "Advances in Experimental Medicine and Biology",

publisher = "Springer New York LLC",

pages = "493--499",

editor = "Elwell, \{Clare E.\} and Leung, \{Terence S.\} and Harrison, \{David K.\}",

booktitle = "Oxygen Transport to Tissue XXXVII",

}

Mitra, S, Bale, G, Meek, J, Mathieson, S, Uria, C, Kendall, G, Robertson, NJ & Tachtsidis, I 2016, In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke. in CE Elwell, TS Leung & DK Harrison (eds), Oxygen Transport to Tissue XXXVII. Advances in Experimental Medicine and Biology, vol. 876, Springer New York LLC, pp. 493-499, 42nd Annual Meeting of International Society on Oxygen Transport to Tissue, London, United Kingdom, 28/06/14. https://doi.org/10.1007/978-1-4939-3023-4_62

In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke. / Mitra, Subhabrata; Bale, Gemma; Meek, Judith et al.
Oxygen Transport to Tissue XXXVII. ed. / Clare E. Elwell; Terence S. Leung; David K. Harrison. Springer New York LLC, 2016. p. 493-499 (Advances in Experimental Medicine and Biology; Vol. 876).

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

TY - GEN

T1 - In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke

AU - Mitra, Subhabrata

AU - Bale, Gemma

AU - Meek, Judith

AU - Mathieson, Sean

AU - Uria, Cristina

AU - Kendall, Giles

AU - Robertson, Nicola J.

AU - Tachtsidis, Ilias

N1 - Publisher Copyright: © The Author(s) 2016.

PY - 2016

Y1 - 2016

N2 - Neonatal stroke presents with features of encephalopathy and can result in significant morbidity and mortality. We investigated the cerebral metabolic and haemodynamic changes following neonatal stroke in a term infant at 24 h of life. Changes in oxidation state of cytochrome-c-oxidase (oxCCO) concentration were monitored along with changes in oxy- and deoxy- haemoglobin using a new broadband near-infrared spectroscopy (NIRS) system. Repeated transient changes in cerebral haemodynamics and metabolism were noted over a 3-h study period with decrease in oxyhaemoglobin (HbO2), deoxy haemoglobin (HHb) and oxCCO in both cerebral hemispheres without significant changes in systemic observations. A clear asymmetry was noted in the degree of change between the two cerebral hemispheres. Changes in cerebral oxygenation (measured as HbDiff=HbO2 -HHb) and cerebral metabolism (measured as oxCCO) were highly coupled on the injured side of the brain.

AB - Neonatal stroke presents with features of encephalopathy and can result in significant morbidity and mortality. We investigated the cerebral metabolic and haemodynamic changes following neonatal stroke in a term infant at 24 h of life. Changes in oxidation state of cytochrome-c-oxidase (oxCCO) concentration were monitored along with changes in oxy- and deoxy- haemoglobin using a new broadband near-infrared spectroscopy (NIRS) system. Repeated transient changes in cerebral haemodynamics and metabolism were noted over a 3-h study period with decrease in oxyhaemoglobin (HbO2), deoxy haemoglobin (HHb) and oxCCO in both cerebral hemispheres without significant changes in systemic observations. A clear asymmetry was noted in the degree of change between the two cerebral hemispheres. Changes in cerebral oxygenation (measured as HbDiff=HbO2 -HHb) and cerebral metabolism (measured as oxCCO) were highly coupled on the injured side of the brain.

KW - Broadband nirs

KW - Cerebral hemodynamics

KW - Cytochrome c oxidase

KW - Mitochondrial metabolism

KW - Neonatal stroke

UR - https://www.scopus.com/pages/publications/84958554987

U2 - 10.1007/978-1-4939-3023-4_62

DO - 10.1007/978-1-4939-3023-4_62

M3 - Conference proceeding

C2 - 26782250

AN - SCOPUS:84958554987

SN - 9781493930227

T3 - Advances in Experimental Medicine and Biology

SP - 493

EP - 499

BT - Oxygen Transport to Tissue XXXVII

A2 - Elwell, Clare E.

A2 - Leung, Terence S.

A2 - Harrison, David K.

PB - Springer New York LLC

T2 - 42nd Annual Meeting of International Society on Oxygen Transport to Tissue

Y2 - 28 June 2014 through 3 July 2014

ER -

Mitra S, Bale G, Meek J, Mathieson S, Uria C, Kendall G et al. In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke. In Elwell CE, Leung TS, Harrison DK, editors, Oxygen Transport to Tissue XXXVII. Springer New York LLC. 2016. p. 493-499. (Advances in Experimental Medicine and Biology). doi: 10.1007/978-1-4939-3023-4_62

In vivo measurement of cerebral mitochondrial metabolism using broadband near infrared spectroscopy following neonatal stroke

Abstract

Publication series

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UN SDGs

Keywords

Access to Document

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