TY - GEN
T1 - In-vivo time-domain diffuse correlation spectroscopy with a superconducting nanowire single-photon detector
AU - Colombo, L.
AU - Lanka, P.
AU - Brodu, A.
AU - Noordzij, N.
AU - Pagliazzi, M.
AU - Parfentyeva, V.
AU - Durduran, T.
AU - Pifferi, A.
N1 - Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.
PY - 2021
Y1 - 2021
N2 - Diffuse correlations spectroscopy (DCS) is a non-invasive optical technique that, studying the speckle intensity fluctuations of light diffused through a biological tissue, measures its microvascular blood flow. Typically, a long coherence length continuous wave source is used, which limits the possibility to resolve the photon path lengths. Recently, time-domain (TD) DCS was proposed, where a pulsed yet coherent light source is used to resolve the speckle fluctuations at different time-of-flights. Due to the constraint of single-speckle detection and time-resolved acquisition, the technique has a limited throughput which limits depth sensitivity. Here, we demonstrate TD DCS with a superconducting nanowire single-photon detector (SNSPD). The SNSPD has a high quantum efficiency and temporal resolution, while maintaining a very low background and no after-pulsing.We report results on phantom and in vivo experiments, which show the potentiality of the proposed detection system for highly accurate TD DCS experiments.
AB - Diffuse correlations spectroscopy (DCS) is a non-invasive optical technique that, studying the speckle intensity fluctuations of light diffused through a biological tissue, measures its microvascular blood flow. Typically, a long coherence length continuous wave source is used, which limits the possibility to resolve the photon path lengths. Recently, time-domain (TD) DCS was proposed, where a pulsed yet coherent light source is used to resolve the speckle fluctuations at different time-of-flights. Due to the constraint of single-speckle detection and time-resolved acquisition, the technique has a limited throughput which limits depth sensitivity. Here, we demonstrate TD DCS with a superconducting nanowire single-photon detector (SNSPD). The SNSPD has a high quantum efficiency and temporal resolution, while maintaining a very low background and no after-pulsing.We report results on phantom and in vivo experiments, which show the potentiality of the proposed detection system for highly accurate TD DCS experiments.
KW - Diffuse correlation spectroscopy
KW - Diffuse Optics
KW - Time-resolved spectroscopy
UR - https://www.scopus.com/pages/publications/85122862669
U2 - 10.1117/12.2614302
DO - 10.1117/12.2614302
M3 - Conference proceeding
AN - SCOPUS:85122862669
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Diffuse Optical Spectroscopy and Imaging VIII
A2 - Contini, Davide
A2 - Hoshi, Yoko
A2 - O'Sullivan, Thomas D.
PB - SPIE
T2 - Diffuse Optical Spectroscopy and Imaging VIII 2021
Y2 - 20 June 2021 through 24 June 2021
ER -