Increasing Objectivity in Quantitative Analysis in Immune-Histochemistry Biomarker Mapping using Upconverting Nanoparticles

Matthias Mickert; Magnus Helgstrand; Sanathana Konugolu Venkata Sekar; Hui Ma; Katarzyna Komolibus; Kiang Wei Kho; Andreas Johansson; Sanna Wallenborg; Stefan Andersson-Engels

doi:10.1364/OMP.2025.OTU1E.2

Increasing Objectivity in Quantitative Analysis in Immune-Histochemistry Biomarker Mapping using Upconverting Nanoparticles

Matthias Mickert
, Magnus Helgstrand
, Sanathana Konugolu Venkata Sekar
, Hui Ma
, Katarzyna Komolibus
, Kiang Wei Kho
, Andreas Johansson
, Sanna Wallenborg
, Stefan Andersson-Engels

Research output: Contribution to conference › Paper › peer-review

Abstract

Today immunohistochemistry (IHC) stains molecular biomarkers for treatment stratification. IHC can become increasingly objective by improving sensitivity, quantification and multiplexing capabilities. We use upconverting nanoparticles to achieve this, potentially leading to improved treatment outcomes.

Original language	English
DOIs	https://doi.org/10.1364/OMP.2025.OTU1E.2
Publication status	Published - 2025
Event	2025 Optical Molecular Probes, Imaging and Drug Delivery, OMP 2025 - Coronado, United States Duration: 21 Apr 2025 → 24 Apr 2025

Conference

Conference	2025 Optical Molecular Probes, Imaging and Drug Delivery, OMP 2025
Country/Territory	United States
City	Coronado
Period	21/04/25 → 24/04/25

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10.1364/OMP.2025.OTU1E.2

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Mickert, M., Helgstrand, M., Sekar, S. K. V., Ma, H., Komolibus, K., Kho, K. W., Johansson, A., Wallenborg, S., & Andersson-Engels, S. (2025). Increasing Objectivity in Quantitative Analysis in Immune-Histochemistry Biomarker Mapping using Upconverting Nanoparticles. Paper presented at 2025 Optical Molecular Probes, Imaging and Drug Delivery, OMP 2025, Coronado, United States. https://doi.org/10.1364/OMP.2025.OTU1E.2

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title = "Increasing Objectivity in Quantitative Analysis in Immune-Histochemistry Biomarker Mapping using Upconverting Nanoparticles",

abstract = "Today immunohistochemistry (IHC) stains molecular biomarkers for treatment stratification. IHC can become increasingly objective by improving sensitivity, quantification and multiplexing capabilities. We use upconverting nanoparticles to achieve this, potentially leading to improved treatment outcomes.",

author = "Matthias Mickert and Magnus Helgstrand and Sekar, \{Sanathana Konugolu Venkata\} and Hui Ma and Katarzyna Komolibus and Kho, \{Kiang Wei\} and Andreas Johansson and Sanna Wallenborg and Stefan Andersson-Engels",

note = "Publisher Copyright: {\textcopyright} Optica Publishing Group {\textcopyright} 2025 The Author(s).; 2025 Optical Molecular Probes, Imaging and Drug Delivery, OMP 2025 ; Conference date: 21-04-2025 Through 24-04-2025",

year = "2025",

doi = "10.1364/OMP.2025.OTU1E.2",

language = "English",

}

Mickert, M, Helgstrand, M, Sekar, SKV, Ma, H, Komolibus, K, Kho, KW, Johansson, A, Wallenborg, S & Andersson-Engels, S 2025, 'Increasing Objectivity in Quantitative Analysis in Immune-Histochemistry Biomarker Mapping using Upconverting Nanoparticles', Paper presented at 2025 Optical Molecular Probes, Imaging and Drug Delivery, OMP 2025, Coronado, United States, 21/04/25 - 24/04/25. https://doi.org/10.1364/OMP.2025.OTU1E.2

Increasing Objectivity in Quantitative Analysis in Immune-Histochemistry Biomarker Mapping using Upconverting Nanoparticles. / Mickert, Matthias; Helgstrand, Magnus; Sekar, Sanathana Konugolu Venkata et al.
2025. Paper presented at 2025 Optical Molecular Probes, Imaging and Drug Delivery, OMP 2025, Coronado, United States.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - Increasing Objectivity in Quantitative Analysis in Immune-Histochemistry Biomarker Mapping using Upconverting Nanoparticles

AU - Mickert, Matthias

AU - Helgstrand, Magnus

AU - Sekar, Sanathana Konugolu Venkata

AU - Ma, Hui

AU - Komolibus, Katarzyna

AU - Kho, Kiang Wei

AU - Johansson, Andreas

AU - Wallenborg, Sanna

AU - Andersson-Engels, Stefan

PY - 2025

Y1 - 2025

N2 - Today immunohistochemistry (IHC) stains molecular biomarkers for treatment stratification. IHC can become increasingly objective by improving sensitivity, quantification and multiplexing capabilities. We use upconverting nanoparticles to achieve this, potentially leading to improved treatment outcomes.

AB - Today immunohistochemistry (IHC) stains molecular biomarkers for treatment stratification. IHC can become increasingly objective by improving sensitivity, quantification and multiplexing capabilities. We use upconverting nanoparticles to achieve this, potentially leading to improved treatment outcomes.

UR - https://www.scopus.com/pages/publications/105011292936

U2 - 10.1364/OMP.2025.OTU1E.2

DO - 10.1364/OMP.2025.OTU1E.2

M3 - Paper

AN - SCOPUS:105011292936

T2 - 2025 Optical Molecular Probes, Imaging and Drug Delivery, OMP 2025

Y2 - 21 April 2025 through 24 April 2025

ER -

Increasing Objectivity in Quantitative Analysis in Immune-Histochemistry Biomarker Mapping using Upconverting Nanoparticles

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