TY - JOUR
T1 - Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia
AU - Kittel-Schneider, S.
AU - Wobrock, T.
AU - Scherk, H.
AU - Schneider-Axmann, T.
AU - Trost, S.
AU - Zilles, D.
AU - Wolf, C.
AU - Schmitt, A.
AU - Malchow, B.
AU - Hasan, A.
AU - Backens, M.
AU - Reith, W.
AU - Falkai, P.
AU - Gruber, O.
AU - Reif, A.
N1 - Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
PY - 2015/3
Y1 - 2015/3
N2 - The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD.
AB - The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD.
KW - Amygdala
KW - Bipolar disorder
KW - DGKH
KW - Schizophrenia
KW - Structural MRI
UR - https://www.scopus.com/pages/publications/84939890925
U2 - 10.1007/s00406-014-0513-9
DO - 10.1007/s00406-014-0513-9
M3 - Article
C2 - 24958494
AN - SCOPUS:84939890925
SN - 0940-1334
VL - 265
SP - 127
EP - 136
JO - European Archives of Psychiatry and Clinical Neuroscience
JF - European Archives of Psychiatry and Clinical Neuroscience
IS - 2
ER -