Intestinal entry of prions

S. Ghosh

doi:10.1055/s-2002-19641

Intestinal entry of prions

S. Ghosh

Imperial College London

Research output: Contribution to journal › Review article › peer-review

Abstract

Variant Creutzfeldt-Jakob disease is thought to be caused by infected prion protein via ingestion of contaminated beef. After ingestion of infected prion proteins, uptake by small intestine may be by either M-cell dependent or M-cell independent routes. A receptor for prion protein, laminin receptor precursor is expressed on the brush border of small intestinal epithelium in 40% of subjects. The cellular prion protein expressed on the enteric nervous system might serve as the target for conversion to infectious prion protein and a route for spread to the central nervous system.

Original language	English
Pages (from-to)	37-39
Number of pages	3
Journal	Zeitschrift fur Gastroenterologie
Volume	40
Issue number	1
DOIs	https://doi.org/10.1055/s-2002-19641
Publication status	Published - 2002
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Laminin Receptor Protein
Prions
Small Intestine
Variant CJD

Access to Document

10.1055/s-2002-19641

Cite this

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title = "Intestinal entry of prions",

abstract = "Variant Creutzfeldt-Jakob disease is thought to be caused by infected prion protein via ingestion of contaminated beef. After ingestion of infected prion proteins, uptake by small intestine may be by either M-cell dependent or M-cell independent routes. A receptor for prion protein, laminin receptor precursor is expressed on the brush border of small intestinal epithelium in 40\% of subjects. The cellular prion protein expressed on the enteric nervous system might serve as the target for conversion to infectious prion protein and a route for spread to the central nervous system.",

keywords = "Laminin Receptor Protein, Prions, Small Intestine, Variant CJD",

author = "S. Ghosh",

year = "2002",

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journal = "Zeitschrift fur Gastroenterologie",

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T1 - Intestinal entry of prions

AU - Ghosh, S.

PY - 2002

Y1 - 2002

N2 - Variant Creutzfeldt-Jakob disease is thought to be caused by infected prion protein via ingestion of contaminated beef. After ingestion of infected prion proteins, uptake by small intestine may be by either M-cell dependent or M-cell independent routes. A receptor for prion protein, laminin receptor precursor is expressed on the brush border of small intestinal epithelium in 40% of subjects. The cellular prion protein expressed on the enteric nervous system might serve as the target for conversion to infectious prion protein and a route for spread to the central nervous system.

AB - Variant Creutzfeldt-Jakob disease is thought to be caused by infected prion protein via ingestion of contaminated beef. After ingestion of infected prion proteins, uptake by small intestine may be by either M-cell dependent or M-cell independent routes. A receptor for prion protein, laminin receptor precursor is expressed on the brush border of small intestinal epithelium in 40% of subjects. The cellular prion protein expressed on the enteric nervous system might serve as the target for conversion to infectious prion protein and a route for spread to the central nervous system.

KW - Laminin Receptor Protein

KW - Prions

KW - Small Intestine

KW - Variant CJD

UR - https://www.scopus.com/pages/publications/0036164296

U2 - 10.1055/s-2002-19641

DO - 10.1055/s-2002-19641

M3 - Review article

C2 - 11803499

AN - SCOPUS:0036164296

SN - 0044-2771

VL - 40

SP - 37

EP - 39

JO - Zeitschrift fur Gastroenterologie

JF - Zeitschrift fur Gastroenterologie

IS - 1

ER -

Intestinal entry of prions

Abstract

UN SDGs

Keywords

Access to Document

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