Is brain arousal regulation a predictor of response to psychostimulant therapy in adult ADHD patients?

Maria Strauß; Andreas Reif; Christine Ulke; Madlen Paucke; Christian Sander; Ulrich Hegerl; Heike Weber; Julia Heupel; Juliane Kopf; Sarah Kittel-Schneider

doi:10.1007/s00406-019-01085-y

Is brain arousal regulation a predictor of response to psychostimulant therapy in adult ADHD patients?

Maria Strauß
, Andreas Reif
, Christine Ulke
, Madlen Paucke
, Christian Sander
, Ulrich Hegerl
, Heike Weber
, Julia Heupel
, Juliane Kopf
, Sarah Kittel-Schneider

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated whether baseline brain arousal instability during resting state EEG, using the Vigilance Algorithm Leipzig (VIGALL 2.1), can predict response to methylphenidate therapy in adult ADHD patients. An arousal stability score of the EEGs of 28 adult ADHD patients was calculated quantifying the extent of arousal decline. In logistic regression analysis, arousal stability score predicted response to MPH [odds ratio 1.28 (95% CI 1.0–1.65); p = 0.027]. In this pilot study, we demonstrated that arousal stability at baseline predicted methylphenidate treatment response, indicating that less stable arousal regulation during a 15-min EEG at rest increases the chance of treatment response.

Original language	English
Pages (from-to)	1073-1076
Number of pages	4
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	270
Issue number	8
DOIs	https://doi.org/10.1007/s00406-019-01085-y
Publication status	Published - 1 Dec 2020
Externally published	Yes

Keywords

ADHD
EEG
Stimulants
Treatment response biomarker
Vigilance

Access to Document

10.1007/s00406-019-01085-y

Cite this

@article{e5cf0a8c630846cab6a590867aceefd6,

title = "Is brain arousal regulation a predictor of response to psychostimulant therapy in adult ADHD patients?",

abstract = "We investigated whether baseline brain arousal instability during resting state EEG, using the Vigilance Algorithm Leipzig (VIGALL 2.1), can predict response to methylphenidate therapy in adult ADHD patients. An arousal stability score of the EEGs of 28 adult ADHD patients was calculated quantifying the extent of arousal decline. In logistic regression analysis, arousal stability score predicted response to MPH [odds ratio 1.28 (95\% CI 1.0–1.65); p = 0.027]. In this pilot study, we demonstrated that arousal stability at baseline predicted methylphenidate treatment response, indicating that less stable arousal regulation during a 15-min EEG at rest increases the chance of treatment response.",

keywords = "ADHD, EEG, Stimulants, Treatment response biomarker, Vigilance",

author = "Maria Strau{\ss} and Andreas Reif and Christine Ulke and Madlen Paucke and Christian Sander and Ulrich Hegerl and Heike Weber and Julia Heupel and Juliane Kopf and Sarah Kittel-Schneider",

note = "Publisher Copyright: {\textcopyright} 2019, Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2020",

month = dec,

day = "1",

doi = "10.1007/s00406-019-01085-y",

language = "English",

volume = "270",

pages = "1073--1076",

journal = "European Archives of Psychiatry and Clinical Neuroscience",

issn = "0940-1334",