Lack of permanent nigrostriatal dopamine deficit following 6-hydroxydopamine injection into the rat striatum

J. Opacka-Juffry; S. Ashworth; A. M. Sullivan; R. B. Banati; S. B. Blunt

doi:10.1007/BF01271256

Lack of permanent nigrostriatal dopamine deficit following 6-hydroxydopamine injection into the rat striatum

J. Opacka-Juffry
, S. Ashworth
, A. M. Sullivan
, R. B. Banati
, S. B. Blunt

Research output: Contribution to journal › Article › peer-review

Abstract

The lesion caused by a single 6-hydroxydopamine injection into rat striatum was evaluated. In vivo positron emission tomography using a dopamine reuptake tracer revealed no consistent reduction in striatal dopamine transporter. Amphetamine rotation test was negative up to 18 weeks. A 21% reduction in striatal dopamine seen at 11 weeks was not detectable at 18 weeks. Tyrosine hydroxylase-positive neurone counts showed no decline in substantia nigra. Our results suggest that this lesion may be subject to compensation and therefore should be used with caution in studies on neuroprotective treatments of Parkinson' disease.

Original language	English
Pages (from-to)	1429-1434
Number of pages	6
Journal	Journal of Neural Transmission
Volume	103
Issue number	12
DOIs	https://doi.org/10.1007/BF01271256
Publication status	Published - 1996
Externally published	Yes

Keywords

6-OHDA
Partial lesion
PET

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10.1007/BF01271256

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title = "Lack of permanent nigrostriatal dopamine deficit following 6-hydroxydopamine injection into the rat striatum",

abstract = "The lesion caused by a single 6-hydroxydopamine injection into rat striatum was evaluated. In vivo positron emission tomography using a dopamine reuptake tracer revealed no consistent reduction in striatal dopamine transporter. Amphetamine rotation test was negative up to 18 weeks. A 21\% reduction in striatal dopamine seen at 11 weeks was not detectable at 18 weeks. Tyrosine hydroxylase-positive neurone counts showed no decline in substantia nigra. Our results suggest that this lesion may be subject to compensation and therefore should be used with caution in studies on neuroprotective treatments of Parkinson' disease.",

keywords = "6-OHDA, Partial lesion, PET",

author = "J. Opacka-Juffry and S. Ashworth and Sullivan, \{A. M.\} and Banati, \{R. B.\} and Blunt, \{S. B.\}",

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doi = "10.1007/BF01271256",

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AU - Opacka-Juffry, J.

AU - Ashworth, S.

AU - Sullivan, A. M.

AU - Banati, R. B.

AU - Blunt, S. B.

PY - 1996

Y1 - 1996

N2 - The lesion caused by a single 6-hydroxydopamine injection into rat striatum was evaluated. In vivo positron emission tomography using a dopamine reuptake tracer revealed no consistent reduction in striatal dopamine transporter. Amphetamine rotation test was negative up to 18 weeks. A 21% reduction in striatal dopamine seen at 11 weeks was not detectable at 18 weeks. Tyrosine hydroxylase-positive neurone counts showed no decline in substantia nigra. Our results suggest that this lesion may be subject to compensation and therefore should be used with caution in studies on neuroprotective treatments of Parkinson' disease.

AB - The lesion caused by a single 6-hydroxydopamine injection into rat striatum was evaluated. In vivo positron emission tomography using a dopamine reuptake tracer revealed no consistent reduction in striatal dopamine transporter. Amphetamine rotation test was negative up to 18 weeks. A 21% reduction in striatal dopamine seen at 11 weeks was not detectable at 18 weeks. Tyrosine hydroxylase-positive neurone counts showed no decline in substantia nigra. Our results suggest that this lesion may be subject to compensation and therefore should be used with caution in studies on neuroprotective treatments of Parkinson' disease.

KW - 6-OHDA

KW - Partial lesion

KW - PET

UR - https://www.scopus.com/pages/publications/0030468096

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EP - 1434

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 12

ER -

Lack of permanent nigrostriatal dopamine deficit following 6-hydroxydopamine injection into the rat striatum

Abstract

Keywords

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