Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

Rebecca E. Deasy; Maude Brossat; Thomas S. Moody; Anita R. Maguire

doi:10.1016/j.tetasy.2010.12.019

Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

Rebecca E. Deasy
, Maude Brossat
, Thomas S. Moody
, Anita R. Maguire

Research output: Contribution to journal › Article › peer-review

Abstract

Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored.

Original language	English
Pages (from-to)	47-61
Number of pages	15
Journal	Tetrahedron Asymmetry
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.tetasy.2010.12.019
Publication status	Published - 17 Jan 2011

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10.1016/j.tetasy.2010.12.019

https://hdl.handle.net/10468/575Licence: CC BY-NC-ND

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title = "Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids",

abstract = "Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94\% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored.",

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AU - Deasy, Rebecca E.

AU - Brossat, Maude

AU - Moody, Thomas S.

AU - Maguire, Anita R.

PY - 2011/1/17

Y1 - 2011/1/17

N2 - Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored.

AB - Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (≥94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored.

UR - https://www.scopus.com/pages/publications/79951813249

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DO - 10.1016/j.tetasy.2010.12.019

M3 - Article

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SN - 0957-4166

VL - 22

SP - 47

EP - 61

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

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ER -

Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

Abstract

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