Lipid-based nanocarriers for oral peptide delivery

Zhigao Niu; Inmaculada Conejos-Sánchez; Brendan T. Griffin; Caitriona M. O'Driscoll; María J. Alonso

doi:10.1016/j.addr.2016.04.001

Lipid-based nanocarriers for oral peptide delivery

Zhigao Niu
, Inmaculada Conejos-Sánchez
, Brendan T. Griffin
, Caitriona M. O'Driscoll
, María J. Alonso

School of Pharmacy

University of Santiago de Compostela

Research output: Contribution to journal › Review article › peer-review

Abstract

This article is aimed to overview the lipid-based nanostructures designed so far for the oral administration of peptides and proteins, and to analyze the influence of their composition and physicochemical (particle size, zeta potential) and pharmaceutical (drug loading and release) properties, on their interaction with the gastro-intestinal environment, and the subsequent PK/PD profile of the associated drugs. The ultimate goal has been to highlight and comparatively analyze the key factors that may be determinant of the success of these nanocarriers for oral peptide delivery. The article ends with some prospects on the challenges to be addressed for the intended commercial success of these delivery vehicles.

Original language	English
Pages (from-to)	337-354
Number of pages	18
Journal	Advanced Drug Delivery Reviews
Volume	106
DOIs	https://doi.org/10.1016/j.addr.2016.04.001
Publication status	Published - 15 Nov 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Lipid formulation
Liposome
Nano/microemulsion
Nanocapsule
Oral delivery
Peptide drug
Self-emulsifying system
Solid lipid nanoparticle

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10.1016/j.addr.2016.04.001

Cite this

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title = "Lipid-based nanocarriers for oral peptide delivery",

abstract = "This article is aimed to overview the lipid-based nanostructures designed so far for the oral administration of peptides and proteins, and to analyze the influence of their composition and physicochemical (particle size, zeta potential) and pharmaceutical (drug loading and release) properties, on their interaction with the gastro-intestinal environment, and the subsequent PK/PD profile of the associated drugs. The ultimate goal has been to highlight and comparatively analyze the key factors that may be determinant of the success of these nanocarriers for oral peptide delivery. The article ends with some prospects on the challenges to be addressed for the intended commercial success of these delivery vehicles.",

keywords = "Lipid formulation, Liposome, Nano/microemulsion, Nanocapsule, Oral delivery, Peptide drug, Self-emulsifying system, Solid lipid nanoparticle",

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doi = "10.1016/j.addr.2016.04.001",

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T1 - Lipid-based nanocarriers for oral peptide delivery

AU - Niu, Zhigao

AU - Conejos-Sánchez, Inmaculada

AU - Griffin, Brendan T.

AU - O'Driscoll, Caitriona M.

AU - Alonso, María J.

PY - 2016/11/15

Y1 - 2016/11/15

N2 - This article is aimed to overview the lipid-based nanostructures designed so far for the oral administration of peptides and proteins, and to analyze the influence of their composition and physicochemical (particle size, zeta potential) and pharmaceutical (drug loading and release) properties, on their interaction with the gastro-intestinal environment, and the subsequent PK/PD profile of the associated drugs. The ultimate goal has been to highlight and comparatively analyze the key factors that may be determinant of the success of these nanocarriers for oral peptide delivery. The article ends with some prospects on the challenges to be addressed for the intended commercial success of these delivery vehicles.

AB - This article is aimed to overview the lipid-based nanostructures designed so far for the oral administration of peptides and proteins, and to analyze the influence of their composition and physicochemical (particle size, zeta potential) and pharmaceutical (drug loading and release) properties, on their interaction with the gastro-intestinal environment, and the subsequent PK/PD profile of the associated drugs. The ultimate goal has been to highlight and comparatively analyze the key factors that may be determinant of the success of these nanocarriers for oral peptide delivery. The article ends with some prospects on the challenges to be addressed for the intended commercial success of these delivery vehicles.

KW - Lipid formulation

KW - Liposome

KW - Nano/microemulsion

KW - Nanocapsule

KW - Oral delivery

KW - Peptide drug

KW - Self-emulsifying system

KW - Solid lipid nanoparticle

UR - https://www.scopus.com/pages/publications/84963954616

U2 - 10.1016/j.addr.2016.04.001

DO - 10.1016/j.addr.2016.04.001

M3 - Review article

C2 - 27080735

AN - SCOPUS:84963954616

SN - 0169-409X

VL - 106

SP - 337

EP - 354

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Lipid-based nanocarriers for oral peptide delivery

Abstract

UN SDGs

Keywords

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