Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors

C. G.* Collins; M.* Tangney; J. O. Larkin; G. Casey; M. C. Whelan; D. Soden; S. Vejda; S. McKenna; B. Kiely; S. Aarons

doi:10.1038/sj.cgt.7700976

Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors

C. G.* Collins
, M.* Tangney
, J. O. Larkin
, G. Casey
, M. C. Whelan
, D. Soden
, S. Vejda
, S. McKenna
, B. Kiely
, S. Aarons

College of Medicine and Health Office

Research output: Contribution to journal › Article › peer-review

Abstract

Gene therapy-induced expression of immunostimulatory molecules at tumor cell level may evoke antitumor immune mechanisms by recruiting and enhancing viability of antigen-processing cells and specific tumoricidal lymphocytes. The antitumor efficacy of a plasmid, coding for granulocyte-macrophage colony-stimulating factor (GM-CSF) and the B7-1 costimulatory immune molecule, delivered into growing solid tumors by electroporation was investigated. Murine fibrosarcomas (JBS) growing in Balb/C mice (

Original language	English
Pages (from-to)	1061-1071
Number of pages	11
Journal	Cancer Gene Therapy
Volume	13
Issue number	12
DOIs	https://doi.org/10.1038/sj.cgt.7700976
Publication status	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals Antigens, CD80/*genetics CD8-Positive T-Lymphocytes/immunology Cell Line, Tumor/pathology Cell Transplantation Cytotoxicity Tests, Immunologic Electroporation/instrumentation/methods Female Fibrosarcoma/genetics/immunology/pathology/*therapy Gene Therapy/*methods Genetic Vectors/genetics/immunology/*pharmacology Granulocyte-Macrophage Colony-Stimulating Factor/*genetics Liver Neoplasms/pathology/secondary/therapy Lymphocytes/immunology Mice Mice, Nude Plasmids/genetics Transfection

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title = "Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors",

abstract = "Gene therapy-induced expression of immunostimulatory molecules at tumor cell level may evoke antitumor immune mechanisms by recruiting and enhancing viability of antigen-processing cells and specific tumoricidal lymphocytes. The antitumor efficacy of a plasmid, coding for granulocyte-macrophage colony-stimulating factor (GM-CSF) and the B7-1 costimulatory immune molecule, delivered into growing solid tumors by electroporation was investigated. Murine fibrosarcomas (JBS) growing in Balb/C mice (",

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author = "Collins, \{C. G.*\} and M.* Tangney and Larkin, \{J. O.\} and G. Casey and Whelan, \{M. C.\} and D. Soden and S. Vejda and S. McKenna and B. Kiely and S. Aarons",

note = "Collins, C G Tangney, M Larkin, J O Casey, G Whelan, M C Cashman, J Murphy, J Soden, D Vejda, S McKenna, S Kiely, B Collins, J K Barrett, J Aarons, S O'Sullivan, G C Research Support, Non-U.S. Gov't England Cancer gene therapy Cancer Gene Ther. 2006 Dec;13(12):1061-71. Epub 2006 Jul 28.",

year = "2006",

doi = "10.1038/sj.cgt.7700976",

language = "English",

volume = "13",

pages = "1061--1071",

journal = "Cancer Gene Therapy",

issn = "0929-1903",

publisher = "Springer Nature",

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T1 - Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors

AU - Collins, C. G.

AU - Tangney, M.

AU - Larkin, J. O.

AU - Casey, G.

AU - Whelan, M. C.

AU - Soden, D.

AU - Vejda, S.

AU - McKenna, S.

AU - Kiely, B.

AU - Aarons, S.

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PY - 2006

Y1 - 2006

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AB - Gene therapy-induced expression of immunostimulatory molecules at tumor cell level may evoke antitumor immune mechanisms by recruiting and enhancing viability of antigen-processing cells and specific tumoricidal lymphocytes. The antitumor efficacy of a plasmid, coding for granulocyte-macrophage colony-stimulating factor (GM-CSF) and the B7-1 costimulatory immune molecule, delivered into growing solid tumors by electroporation was investigated. Murine fibrosarcomas (JBS) growing in Balb/C mice (

KW - Animals Antigens, CD80/genetics CD8-Positive T-Lymphocytes/immunology Cell Line, Tumor/pathology Cell Transplantation Cytotoxicity Tests, Immunologic Electroporation/instrumentation/methods Female Fibrosarcoma/genetics/immunology/pathology/therapy Gene Th

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DO - 10.1038/sj.cgt.7700976

M3 - Article

SN - 0929-1903

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SP - 1061

EP - 1071

JO - Cancer Gene Therapy

JF - Cancer Gene Therapy

IS - 12

ER -

Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors

Abstract

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Keywords

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