Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity

Aaran J. Flynn; Alan Ford; Anita R. Maguire

doi:10.1021/acs.joc.0c01094

Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity

Aaran J. Flynn
, Alan Ford
, Anita R. Maguire

Research output: Contribution to journal › Article › peer-review

Abstract

Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.

Original language	English
Pages (from-to)	10216-10221
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	85
Issue number	15
DOIs	https://doi.org/10.1021/acs.joc.0c01094
Publication status	Published - 7 Aug 2020

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https://hdl.handle.net/10468/10542Licence: CC BY-NC-ND

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title = "Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity",

abstract = "Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.",

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AB - Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.

UR - https://www.scopus.com/pages/publications/85090281171

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Localized Partitioning of Enantiomers in Solid Samples of Sulfoxides: Importance of Sampling Method in Determination of Enantiopurity

Abstract

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