Magnetic biosensors for genetic screening of cystic fibrosis

L. Lagae; R. Wirix-Speetjens; C. X. Liu; W. Laureyn; G. Borghs; S. Harvey; P. Galvin; H. A. Ferreira; D. L. Graham; P. P. Freitas; L. A. Clarke; M. D. Amaral

doi:10.1049/ip-cds:20050022

Magnetic biosensors for genetic screening of cystic fibrosis

L. Lagae
, R. Wirix-Speetjens
, C. X. Liu
, W. Laureyn
, G. Borghs
, S. Harvey
, P. Galvin
, H. A. Ferreira
, D. L. Graham
, P. P. Freitas
, L. A. Clarke
, M. D. Amaral

Interuniversitair Micro-Elektronica Centrum
Instituto de Engenharia de Sistemas e Computadores, Investigação e Desenvolvimento em Lisboa
University of Lisbon

Research output: Contribution to journal › Article › peer-review

Abstract

The paper reports on the development of a magnetic biosensing platform for genetic analysis. The sensing technique is based on the on-chip manipulation of magnetically labelled biomolecules by the magnetic field gradient force created by current-carrying conductors; on biomolecular reactions such as the binding of complementary DNA material; and on the detection of the fringe field of the magnetic label by a magnetoresistive spin valve sensor. Different experiments will demonstrate the advantages, difficulties, prospects and potential of the combination of magnetic bead manipulation and detection on a single microchip. Early detection of DNA coding for the cystic fibrosis (CF) gene is used as a model system for proof-of-concept of the magnetic DNA biosensor platform.

Original language	English
Pages (from-to)	393-400
Number of pages	8
Journal	IEE Proceedings: Circuits, Devices and Systems
Volume	152
Issue number	4
DOIs	https://doi.org/10.1049/ip-cds:20050022
Publication status	Published - Aug 2005

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title = "Magnetic biosensors for genetic screening of cystic fibrosis",

abstract = "The paper reports on the development of a magnetic biosensing platform for genetic analysis. The sensing technique is based on the on-chip manipulation of magnetically labelled biomolecules by the magnetic field gradient force created by current-carrying conductors; on biomolecular reactions such as the binding of complementary DNA material; and on the detection of the fringe field of the magnetic label by a magnetoresistive spin valve sensor. Different experiments will demonstrate the advantages, difficulties, prospects and potential of the combination of magnetic bead manipulation and detection on a single microchip. Early detection of DNA coding for the cystic fibrosis (CF) gene is used as a model system for proof-of-concept of the magnetic DNA biosensor platform.",

author = "L. Lagae and R. Wirix-Speetjens and Liu, \{C. X.\} and W. Laureyn and G. Borghs and S. Harvey and P. Galvin and Ferreira, \{H. A.\} and Graham, \{D. L.\} and Freitas, \{P. P.\} and Clarke, \{L. A.\} and Amaral, \{M. D.\}",

year = "2005",

month = aug,

doi = "10.1049/ip-cds:20050022",

language = "English",

volume = "152",

pages = "393--400",

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T1 - Magnetic biosensors for genetic screening of cystic fibrosis

AU - Lagae, L.

AU - Wirix-Speetjens, R.

AU - Liu, C. X.

AU - Laureyn, W.

AU - Borghs, G.

AU - Harvey, S.

AU - Galvin, P.

AU - Ferreira, H. A.

AU - Graham, D. L.

AU - Freitas, P. P.

AU - Clarke, L. A.

AU - Amaral, M. D.

PY - 2005/8

Y1 - 2005/8

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AB - The paper reports on the development of a magnetic biosensing platform for genetic analysis. The sensing technique is based on the on-chip manipulation of magnetically labelled biomolecules by the magnetic field gradient force created by current-carrying conductors; on biomolecular reactions such as the binding of complementary DNA material; and on the detection of the fringe field of the magnetic label by a magnetoresistive spin valve sensor. Different experiments will demonstrate the advantages, difficulties, prospects and potential of the combination of magnetic bead manipulation and detection on a single microchip. Early detection of DNA coding for the cystic fibrosis (CF) gene is used as a model system for proof-of-concept of the magnetic DNA biosensor platform.

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DO - 10.1049/ip-cds:20050022

M3 - Article

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EP - 400

JO - IEE Proceedings: Circuits, Devices and Systems

JF - IEE Proceedings: Circuits, Devices and Systems

IS - 4

ER -

Magnetic biosensors for genetic screening of cystic fibrosis

Abstract

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