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Management of pouch neoplasia: consensus guidelines from the International Ileal Pouch Consortium

  • Ravi P. Kiran
  • , Gursimran S. Kochhar
  • , Revital Kariv
  • , Douglas K. Rex
  • , Akira Sugita
  • , David T. Rubin
  • , Udayakumar Navaneethan
  • , Tracy L. Hull
  • , Huaibin Mabel Ko
  • , Xiuli Liu
  • , Lisa A. Kachnic
  • , Scott Strong
  • , Marietta Iacucci
  • , Willem Bemelman
  • , Philip Fleshner
  • , Rachael A. Safyan
  • , Paulo G. Kotze
  • , André D'Hoore
  • , Omar Faiz
  • , Simon Lo
  • Jean H. Ashburn, Antonino Spinelli, Charles N. Bernstein, Sunanda V. Kane, Raymond K. Cross, Jason Schairer, James T. McCormick, Francis A. Farraye, Shannon Chang, Ellen J. Scherl, David A. Schwartz, David H. Bruining, Jessica Philpott, Stuart Bentley-Hibbert, Dino Tarabar, Sandra El-Hachem, William J. Sandborn, Mark S. Silverberg, Darrell S. Pardi, James M. Church, Bo Shen
  • Columbia University
  • West Penn Allegheny Health System
  • Tel Aviv University
  • Indiana University Bloomington
  • Yokohama Municipal Citizen's Hospital
  • The University of Chicago
  • Orlando Regional Medical Center
  • Cleveland Clinic Foundation
  • Washington University St. Louis
  • Northwestern University
  • University Hospitals Birmingham NHS Foundation Trust
  • Amsterdam University Medical Centers
  • Cedars-Sinai Medical Center
  • Pontifícia Universidade Católica do Paraná
  • KU Leuven
  • London North West University Healthcare NHS Trust
  • Wake Forest University
  • IRCCS Istituto Clinico Humanitas - Rozzano (Milano)
  • University of Manitoba
  • Mayo Clinic Rochester, MN
  • University of Maryland, Baltimore
  • Henry Ford Health System
  • Mayo Clinic in Jacksonville, Florida
  • New York University
  • Cornell University
  • Vanderbilt University
  • University Hospital Center Dr Dragiša Mišović
  • University of California at San Diego
  • University of Toronto

Research output: Contribution to journalReview articlepeer-review

Abstract

Surveillance pouchoscopy is recommended for patients with restorative proctocolectomy with ileal pouch–anal anastomosis in ulcerative colitis or familial adenomatous polyposis, with the surveillance interval depending on the risk of neoplasia. Neoplasia in patients with ileal pouches mainly have a glandular source and less often are of squamous cell origin. Various grades of neoplasia can occur in the prepouch ileum, pouch body, rectal cuff, anal transition zone, anus, or perianal skin. The main treatment modalities are endoscopic polypectomy, endoscopic ablation, endoscopic mucosal resection, endoscopic submucosal dissection, surgical local excision, surgical circumferential resection and re-anastomosis, and pouch excision. The choice of the treatment modality is determined by the grade, location, size, and features of neoplastic lesions, along with patients' risk of neoplasia and comorbidities, and local endoscopic and surgical expertise.

Original languageEnglish
Pages (from-to)871-893
Number of pages23
JournalThe Lancet Gastroenterology and Hepatology
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 2022
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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