Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

the SCOPE Consortium

doi:10.1007/s10803-021-05271-7

Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

the SCOPE Consortium

University College Cork
The University of Auckland

Research output: Contribution to journal › Article › peer-review

Abstract

Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.

Original language	English
Pages (from-to)	3919-3932
Number of pages	14
Journal	Journal of Autism and Developmental Disorders
Volume	52
Issue number	9
DOIs	https://doi.org/10.1007/s10803-021-05271-7
Publication status	Published - Sep 2022

Keywords

Autism spectrum disorder
Cytokine
IL-17A
Inflammation
Maternal immune activation

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10.1007/s10803-021-05271-7

https://hdl.handle.net/10468/15868Licence: CC BY

Cite this

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title = "Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder",

abstract = "Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.",

keywords = "Autism spectrum disorder, Cytokine, IL-17A, Inflammation, Maternal immune activation",

author = "\{the SCOPE Consortium\} and S. Casey and M. Carter and Looney, \{A. M.\} and V. Livingstone and G. Moloney and O{\textquoteright}Keeffe, \{G. W.\} and Taylor, \{R. S.\} and Kenny, \{L. C.\} and McCarthy, \{F. P.\} and McCowan, \{L. M.E.\} and Thompson, \{J. M.D.\} and Murray, \{D. M.\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2022",

month = sep,

doi = "10.1007/s10803-021-05271-7",

language = "English",

volume = "52",

pages = "3919--3932",

journal = "Journal of Autism and Developmental Disorders",

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T1 - Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

AU - the SCOPE Consortium

AU - Casey, S.

AU - Carter, M.

AU - Looney, A. M.

AU - Livingstone, V.

AU - Moloney, G.

AU - O’Keeffe, G. W.

AU - Taylor, R. S.

AU - Kenny, L. C.

AU - McCarthy, F. P.

AU - McCowan, L. M.E.

AU - Thompson, J. M.D.

AU - Murray, D. M.

PY - 2022/9

Y1 - 2022/9

N2 - Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.

AB - Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment.

KW - Autism spectrum disorder

KW - Cytokine

KW - IL-17A

KW - Inflammation

KW - Maternal immune activation

UR - https://www.scopus.com/pages/publications/85114723315

U2 - 10.1007/s10803-021-05271-7

DO - 10.1007/s10803-021-05271-7

M3 - Article

C2 - 34505185

AN - SCOPUS:85114723315

SN - 0162-3257

VL - 52

SP - 3919

EP - 3932

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 9

ER -

Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

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Investigators from University College Cork Report New Data on Autism Spectrum Disorders (Maternal Mid-gestation Cytokine Dysregulation In Mothers of Children With Autism Spectrum Disorder)

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Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

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Investigators from University College Cork Report New Data on Autism Spectrum Disorders (Maternal Mid-gestation Cytokine Dysregulation In Mothers of Children With Autism Spectrum Disorder)

Cite this