Mathematically modelling hCG in women with gestational trophoblastic disease using logarithmic transformations

Research output: Chapter in Book/Report/Conference proceedingsChapterpeer-review

Abstract

Transformations are a common technique used to linearize data so that simple linear regression can be applied. A common transformation used is the logarithmic transformation. This transforms data that follows an exponential pattern so that a straight line can be fit to it. In this study human chorionic gonadotropin (hCG) levels in women with gestational trophoblastic disease (GTD), which are known to decrease exponentially, are transformed using a logarithmic transformation and the line of best fit is found. A new method is then described including vertical shift in the model. The two methods are tested on data provided by the National Center for GTD in Cork University Maternity Hospital. It was found that the new method described here was more accurate at predicting future hCG measurements.

Original languageEnglish
Title of host publicationProceedings - 2016 UKSim-AMSS 18th International Conference on Computer Modelling and Simulation, UKSim 2016
EditorsGlenn Jenkins, David Al-Dabass, Alessandra Orsoni, Richard Cant
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages55-59
Number of pages5
ISBN (Electronic)9781509008889
DOIs
Publication statusPublished - 22 Dec 2016
Event18th UKSim-AMSS International Conference on Computer Modelling and Simulation, UKSim 2016 - Cambridge, Cambridgeshire, United Kingdom
Duration: 6 Apr 20168 Apr 2016

Publication series

NameProceedings - 2016 UKSim-AMSS 18th International Conference on Computer Modelling and Simulation, UKSim 2016

Conference

Conference18th UKSim-AMSS International Conference on Computer Modelling and Simulation, UKSim 2016
Country/TerritoryUnited Kingdom
CityCambridge, Cambridgeshire
Period6/04/168/04/16

Keywords

  • Gestational trophoblastic disease
  • HCG
  • Logarithmic transformation
  • Mathematical modelling

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