Membrane molecules for mood

David A. Slattery; John F. Cryan

doi:10.1016/j.tins.2021.05.001

Membrane molecules for mood

David A. Slattery
, John F. Cryan

Goethe University Frankfurt

Research output: Contribution to journal › Short survey › peer-review

Abstract

According to the decades-old neurotrophic hypothesis of depression, the delayed actions of antidepressants are purported to be due to their downstream effects on neuronal plasticity. In a recent study, Casarotto et al. reveal that antidepressants can in fact directly bind to the neurotrophin TRKB receptor and exert their effects through this mechanism.

Original language	English
Pages (from-to)	602-604
Number of pages	3
Journal	Trends in Neurosciences
Volume	44
Issue number	8
DOIs	https://doi.org/10.1016/j.tins.2021.05.001
Publication status	Published - Aug 2021

Keywords

antidepressant
BDNF
depression
plasticity

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10.1016/j.tins.2021.05.001

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@article{07e3054ffe5146719283ffffa3fc7eff,

title = "Membrane molecules for mood",

abstract = "According to the decades-old neurotrophic hypothesis of depression, the delayed actions of antidepressants are purported to be due to their downstream effects on neuronal plasticity. In a recent study, Casarotto et al. reveal that antidepressants can in fact directly bind to the neurotrophin TRKB receptor and exert their effects through this mechanism.",

keywords = "antidepressant, BDNF, depression, plasticity",

author = "Slattery, \{David A.\} and Cryan, \{John F.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = aug,

doi = "10.1016/j.tins.2021.05.001",

language = "English",

volume = "44",

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journal = "Trends in Neurosciences",

issn = "0166-2236",

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TY - JOUR

T1 - Membrane molecules for mood

AU - Slattery, David A.

AU - Cryan, John F.

PY - 2021/8

Y1 - 2021/8

N2 - According to the decades-old neurotrophic hypothesis of depression, the delayed actions of antidepressants are purported to be due to their downstream effects on neuronal plasticity. In a recent study, Casarotto et al. reveal that antidepressants can in fact directly bind to the neurotrophin TRKB receptor and exert their effects through this mechanism.

AB - According to the decades-old neurotrophic hypothesis of depression, the delayed actions of antidepressants are purported to be due to their downstream effects on neuronal plasticity. In a recent study, Casarotto et al. reveal that antidepressants can in fact directly bind to the neurotrophin TRKB receptor and exert their effects through this mechanism.

KW - antidepressant

KW - BDNF

KW - depression

KW - plasticity

UR - https://www.scopus.com/pages/publications/85106653157

U2 - 10.1016/j.tins.2021.05.001

DO - 10.1016/j.tins.2021.05.001

M3 - Short survey

C2 - 34053679

AN - SCOPUS:85106653157

SN - 0166-2236

VL - 44

SP - 602

EP - 604

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 8

ER -

Membrane molecules for mood

Abstract

Keywords

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