Meta-analysis of the DRD5 VNTR in persistent ADHD

Marieke Klein; Stefanie Berger; Martine Hoogman; Janneke Dammers; Remco Makkinje; Angelien J.G.A.M. Heister; Tessel E. Galesloot; Lambertus A.L.M. Kiemeney; Heike Weber; Sarah Kittel-Schneider; Klaus Peter Lesch; Andreas Reif; Marta Ribasés; Josep Antoni Ramos-Quiroga; Bru Cormand; Tetyana Zayats; Tor Arne Hegvik; Kaya K. Jacobsen; Stefan Johansson; Jan Haavik; Nina R. Mota; Claiton H.D. Bau; Eugenio H. Grevet; Alysa Doyle; Stephen V. Faraone; Alejandro Arias-Vásquez; Barbara Franke

doi:10.1016/j.euroneuro.2016.06.012

Meta-analysis of the DRD5 VNTR in persistent ADHD

Marieke Klein
, Stefanie Berger
, Martine Hoogman
, Janneke Dammers
, Remco Makkinje
, Angelien J.G.A.M. Heister
, Tessel E. Galesloot
, Lambertus A.L.M. Kiemeney
, Heike Weber
, Sarah Kittel-Schneider
, Klaus Peter Lesch
, Andreas Reif
, Marta Ribasés
, Josep Antoni Ramos-Quiroga
, Bru Cormand
, Tetyana Zayats
, Tor Arne Hegvik
, Kaya K. Jacobsen
, Stefan Johansson
, Jan Haavik

Nina R. Mota, Claiton H.D. Bau, Eugenio H. Grevet, Alysa Doyle, Stephen V. Faraone, Alejandro Arias-Vásquez, Barbara Franke

Radboud University Nijmegen
Goethe University Frankfurt
University of Würzburg
Instituto de Salud Carlos III
Autonomous University of Barcelona
Hospital Universitari Vall d'Hebron
University Hospital
University of Barcelona
Instituto de Salud Carlos III
University of Bergen
Universidade Federal do Rio Grande do Sul
Massachusetts General Hospital
Broad Institute
SUNY Upstate Medical University

Research output: Contribution to journal › Article › peer-review

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. DRD5, the gene encoding the dopamine receptor D5, was recently confirmed as a candidate gene for ADHD in children through meta-analysis. In this study, we aimed at studying the association of the ADHD-associated variable number tandem repeat (VNTR) polymorphism upstream of DRD5 with adult ADHD. We compiled data from six sites of the International Multicentre persistent ADHD CollaboraTion (IMpACT) and reached N=6979 (3344 cases and 3635 healthy participants), the largest sample investigated so far. We tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts. Our findings provide evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults.

Original language	English
Pages (from-to)	1527-1532
Number of pages	6
Journal	European Neuropsychopharmacology
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/j.euroneuro.2016.06.012
Publication status	Published - 1 Sept 2016
Externally published	Yes

Keywords

Attention-Deficit/Hyperactivity Disorder
Candidate gene
DRD5
Meta-analysis

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10.1016/j.euroneuro.2016.06.012

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Klein, M., Berger, S., Hoogman, M., Dammers, J., Makkinje, R., Heister, A. J. G. A. M., Galesloot, T. E., Kiemeney, L. A. L. M., Weber, H., Kittel-Schneider, S., Lesch, K. P., Reif, A., Ribasés, M., Ramos-Quiroga, J. A., Cormand, B., Zayats, T., Hegvik, T. A., Jacobsen, K. K., Johansson, S., ... Franke, B. (2016). Meta-analysis of the DRD5 VNTR in persistent ADHD. European Neuropsychopharmacology, 26(9), 1527-1532. https://doi.org/10.1016/j.euroneuro.2016.06.012

@article{f63f45812f2c4d64981f30bc12e20f7d,

title = "Meta-analysis of the DRD5 VNTR in persistent ADHD",

abstract = "Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. DRD5, the gene encoding the dopamine receptor D5, was recently confirmed as a candidate gene for ADHD in children through meta-analysis. In this study, we aimed at studying the association of the ADHD-associated variable number tandem repeat (VNTR) polymorphism upstream of DRD5 with adult ADHD. We compiled data from six sites of the International Multicentre persistent ADHD CollaboraTion (IMpACT) and reached N=6979 (3344 cases and 3635 healthy participants), the largest sample investigated so far. We tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts. Our findings provide evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults.",

keywords = "Attention-Deficit/Hyperactivity Disorder, Candidate gene, DRD5, Meta-analysis",

author = "Marieke Klein and Stefanie Berger and Martine Hoogman and Janneke Dammers and Remco Makkinje and Heister, \{Angelien J.G.A.M.\} and Galesloot, \{Tessel E.\} and Kiemeney, \{Lambertus A.L.M.\} and Heike Weber and Sarah Kittel-Schneider and Lesch, \{Klaus Peter\} and Andreas Reif and Marta Ribas{\'e}s and Ramos-Quiroga, \{Josep Antoni\} and Bru Cormand and Tetyana Zayats and Hegvik, \{Tor Arne\} and Jacobsen, \{Kaya K.\} and Stefan Johansson and Jan Haavik and Mota, \{Nina R.\} and Bau, \{Claiton H.D.\} and Grevet, \{Eugenio H.\} and Alysa Doyle and Faraone, \{Stephen V.\} and Alejandro Arias-V{\'a}squez and Barbara Franke",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier B.V. and ECNP",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.euroneuro.2016.06.012",

language = "English",

volume = "26",

pages = "1527--1532",

journal = "European Neuropsychopharmacology",

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Klein, M, Berger, S, Hoogman, M, Dammers, J, Makkinje, R, Heister, AJGAM, Galesloot, TE, Kiemeney, LALM, Weber, H, Kittel-Schneider, S, Lesch, KP, Reif, A, Ribasés, M, Ramos-Quiroga, JA, Cormand, B, Zayats, T, Hegvik, TA, Jacobsen, KK, Johansson, S, Haavik, J, Mota, NR, Bau, CHD, Grevet, EH, Doyle, A, Faraone, SV, Arias-Vásquez, A & Franke, B 2016, 'Meta-analysis of the DRD5 VNTR in persistent ADHD', European Neuropsychopharmacology, vol. 26, no. 9, pp. 1527-1532. https://doi.org/10.1016/j.euroneuro.2016.06.012

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AU - Klein, Marieke

AU - Berger, Stefanie

AU - Hoogman, Martine

AU - Dammers, Janneke

AU - Makkinje, Remco

AU - Heister, Angelien J.G.A.M.

AU - Galesloot, Tessel E.

AU - Kiemeney, Lambertus A.L.M.

AU - Weber, Heike

AU - Kittel-Schneider, Sarah

AU - Lesch, Klaus Peter

AU - Reif, Andreas

AU - Ribasés, Marta

AU - Ramos-Quiroga, Josep Antoni

AU - Cormand, Bru

AU - Zayats, Tetyana

AU - Hegvik, Tor Arne

AU - Jacobsen, Kaya K.

AU - Johansson, Stefan

AU - Haavik, Jan

AU - Mota, Nina R.

AU - Bau, Claiton H.D.

AU - Grevet, Eugenio H.

AU - Doyle, Alysa

AU - Faraone, Stephen V.

AU - Arias-Vásquez, Alejandro

AU - Franke, Barbara

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. DRD5, the gene encoding the dopamine receptor D5, was recently confirmed as a candidate gene for ADHD in children through meta-analysis. In this study, we aimed at studying the association of the ADHD-associated variable number tandem repeat (VNTR) polymorphism upstream of DRD5 with adult ADHD. We compiled data from six sites of the International Multicentre persistent ADHD CollaboraTion (IMpACT) and reached N=6979 (3344 cases and 3635 healthy participants), the largest sample investigated so far. We tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts. Our findings provide evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults.

AB - Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. DRD5, the gene encoding the dopamine receptor D5, was recently confirmed as a candidate gene for ADHD in children through meta-analysis. In this study, we aimed at studying the association of the ADHD-associated variable number tandem repeat (VNTR) polymorphism upstream of DRD5 with adult ADHD. We compiled data from six sites of the International Multicentre persistent ADHD CollaboraTion (IMpACT) and reached N=6979 (3344 cases and 3635 healthy participants), the largest sample investigated so far. We tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts. Our findings provide evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults.

KW - Attention-Deficit/Hyperactivity Disorder

KW - Candidate gene

KW - DRD5

KW - Meta-analysis

UR - https://www.scopus.com/pages/publications/84979731402

U2 - 10.1016/j.euroneuro.2016.06.012

DO - 10.1016/j.euroneuro.2016.06.012

M3 - Article

C2 - 27480019

AN - SCOPUS:84979731402

SN - 0924-977X

VL - 26

SP - 1527

EP - 1532

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 9

ER -

Meta-analysis of the DRD5 VNTR in persistent ADHD

Abstract

Keywords

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