TY - JOUR
T1 - Microbiome: A Key Regulator of Body-Brain Interactions.
AU - Kenneth J, O'Riordan
AU - Maria R, Aburto
AU - Nagpal, J
AU - Clarke, G
AU - JF, Cryan
PY - 2025/1/1
Y1 - 2025/1/1
N2 - The gut microbiota, consisting of trillions of microorganisms, plays a critical role in regulating host physiology, including metabolism, immune responses, and brain function. This chapter examines the microbiota-gut-brain axis, a multifaceted bidirectional communication system connecting gut microbial activity with central nervous system processes through immune pathways, metabolic byproducts, and neural circuits like the vagus nerve. The evolution of the gut microbiota throughout an individual's life-from early developmental influences like birth mode and antibiotic use to changes associated with aging and neurodegenerative conditions-highlights its dynamic nature. The chapter reviews experimental approaches and microbiome-based interventions to demonstrate the influence of gut microbiota on neurological conditions such as autism spectrum disorder, anxiety, and Alzheimer's disease. Finally, it emphasises the importance of advancing microbiome-targeted therapies, integrating emerging technologies, and clinical trials to develop personalised strategies for enhancing brain health through gut microbiome modulation.
AB - The gut microbiota, consisting of trillions of microorganisms, plays a critical role in regulating host physiology, including metabolism, immune responses, and brain function. This chapter examines the microbiota-gut-brain axis, a multifaceted bidirectional communication system connecting gut microbial activity with central nervous system processes through immune pathways, metabolic byproducts, and neural circuits like the vagus nerve. The evolution of the gut microbiota throughout an individual's life-from early developmental influences like birth mode and antibiotic use to changes associated with aging and neurodegenerative conditions-highlights its dynamic nature. The chapter reviews experimental approaches and microbiome-based interventions to demonstrate the influence of gut microbiota on neurological conditions such as autism spectrum disorder, anxiety, and Alzheimer's disease. Finally, it emphasises the importance of advancing microbiome-targeted therapies, integrating emerging technologies, and clinical trials to develop personalised strategies for enhancing brain health through gut microbiome modulation.
UR - https://doi.org/10.1007/978-3-031-89525-8_6
U2 - 10.1007/978-3-031-89525-8_6
DO - 10.1007/978-3-031-89525-8_6
M3 - Article
C2 - 40442386
SN - 0065-2598
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -