@inproceedings{6cacc2773e7a450997dac1b92cfce224,
title = "Microneedle sensor for voltammetric drug detection in physiological fluids",
abstract = "This report describes the integration of an electrochemical micro-interface of immiscible fluids in a hollow microneedle. The purpose of such a novel sensor platform is to detect the concentration of drugs in bodily fluids. Although the use of immiscible liquid interfaces is known in electrochemistry, this is the first time that its integration was attempted at a microneedle platform. The benefits of this platform are the ability to detect drugs without the need of extraction of physiological fluid, and contrary to standard electrochemical techniques, the capacity to detect ionic species that aren't susceptible to redox processes. The microneedle platform was able to detect the drug propranolol in physiological buffer. Experiments with differential pulse stripping voltammetry showed a calibration curve with a sensitivity of 43 nAμM-1, and limit of detection of 50 nM, which is pharmaceutically relevant and comparable with previously published highly-sensitive techniques.",
keywords = "ITIES, Micro-interfaces, Microneedles, Minimally invasive, Stripping voltammetry, β-blocker drug",
author = "Patricia Vazquez and Conor O'Mahony and Joseph O'Brien and James Scully and Alan Blake and Cian O'Mathuna and Paul Galvin and Gr{\'e}goire Herzog",
note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 13th IEEE SENSORS Conference, SENSORS 2014 ; Conference date: 02-11-2014 Through 05-11-2014",
year = "2014",
month = dec,
day = "12",
doi = "10.1109/ICSENS.2014.6985367",
language = "English",
series = "Proceedings of IEEE Sensors",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "December",
pages = "1768--1771",
editor = "Arregui, \{Francisco J.\}",
booktitle = "IEEE SENSORS 2014, Proceedings",
address = "United States",
edition = "December",
}