Abstract
A system for multi-colour fluorescence imaging of tissue is described. The instrument is mainly developed for tissue diagnostics to identify and localise malignant tumours, but might also be useful for real-time monitoring of the therapeutic dose delivered during photodynamic therapy. In vivo examples from various malignant skin lesions following topical δ-amino levulinic acid (ALA) administration are presented. The diagnostic system utilises both characteristics of a fluorescent tumour marker, such as a porphyrin containing substance, and the native tissue autofluorescence to characterise the tissue. A dimensionless function of three or four simultaneously recorded fluorescence intensities is formed and an optimum-contrast image is calculated pixel-by-pixel.
| Original language | English |
|---|---|
| Pages (from-to) | 134-143 |
| Number of pages | 10 |
| Journal | Bioimaging |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1995 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 3 Good Health and Well-being
Keywords
- ALA
- Fluorescence spectroscopy
- Imaging
- Photosensitiser
- Skin cancer
- Tissue diagnostics
Fingerprint
Dive into the research topics of 'Multi-colour fluorescence imaging in connection with photodynamic therapy of δ-amino levulinic acid (ALA) sensitised skin malignancies'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver