Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21

Emer E. Hackett; Hugo Charles-Messance; Seónadh M. O'Leary; Laura E. Gleeson; Natalia Muñoz-Wolf; Sarah Case; Anna Wedderburn; Daniel G.W. Johnston; Michelle A. Williams; Alicia Smyth; Mireille Ouimet; Kathryn J. Moore; Ed C. Lavelle; Sinéad C. Corr; Stephen V. Gordon; Joseph Keane; Frederick J. Sheedy

doi:10.1016/j.celrep.2019.12.015

Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21

Emer E. Hackett
, Hugo Charles-Messance
, Seónadh M. O'Leary
, Laura E. Gleeson
, Natalia Muñoz-Wolf
, Sarah Case
, Anna Wedderburn
, Daniel G.W. Johnston
, Michelle A. Williams
, Alicia Smyth
, Mireille Ouimet
, Kathryn J. Moore
, Ed C. Lavelle
, Sinéad C. Corr
, Stephen V. Gordon
, Joseph Keane
, Frederick J. Sheedy

Trinity College Dublin
University College Dublin
New York University

Research output: Contribution to journal › Article › peer-review

Abstract

Hackett et al. identify a role for the anti-inflammatory miR-21 in limiting host glycolysis during tuberculosis (TB) infection to favor bacterial replication. This occurs by targeting a pro-glycolytic isoform at the rate-limiting step in glycolysis, PFK-M, a process antagonized by the host Th1-cytokine IFN-γ, to promote full macrophage activation and antimicrobial function.

Original language	English
Pages (from-to)	124-136.e4
Journal	Cell Reports
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2019.12.015
Publication status	Published - 7 Jan 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

glycolysis
interferon gamma
interleukin-1b
macrophage
metabolic reprogramming
microRNA
miR-21
mycobacterium tuberculosis
phosphofructokinase
tuberculosis

Access to Document

10.1016/j.celrep.2019.12.015

Cite this

Hackett, E. E., Charles-Messance, H., O'Leary, S. M., Gleeson, L. E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D. G. W., Williams, M. A., Smyth, A., Ouimet, M., Moore, K. J., Lavelle, E. C., Corr, S. C., Gordon, S. V., Keane, J., & Sheedy, F. J. (2020). Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21. Cell Reports, 30(1), 124-136.e4. https://doi.org/10.1016/j.celrep.2019.12.015

@article{3077dcde8c8d485ead7f475ec9dec2d6,

title = "Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21",

abstract = "Hackett et al. identify a role for the anti-inflammatory miR-21 in limiting host glycolysis during tuberculosis (TB) infection to favor bacterial replication. This occurs by targeting a pro-glycolytic isoform at the rate-limiting step in glycolysis, PFK-M, a process antagonized by the host Th1-cytokine IFN-γ, to promote full macrophage activation and antimicrobial function.",

keywords = "glycolysis, interferon gamma, interleukin-1b, macrophage, metabolic reprogramming, microRNA, miR-21, mycobacterium tuberculosis, phosphofructokinase, tuberculosis",

author = "Hackett, \{Emer E.\} and Hugo Charles-Messance and O'Leary, \{Se{\'o}nadh M.\} and Gleeson, \{Laura E.\} and Natalia Mu{\~n}oz-Wolf and Sarah Case and Anna Wedderburn and Johnston, \{Daniel G.W.\} and Williams, \{Michelle A.\} and Alicia Smyth and Mireille Ouimet and Moore, \{Kathryn J.\} and Lavelle, \{Ed C.\} and Corr, \{Sin{\'e}ad C.\} and Gordon, \{Stephen V.\} and Joseph Keane and Sheedy, \{Frederick J.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2020",

month = jan,

day = "7",

doi = "10.1016/j.celrep.2019.12.015",

language = "English",

volume = "30",

pages = "124--136.e4",

journal = "Cell Reports",

issn = "2639-1856",

publisher = "Elsevier B.V.",

number = "1",

}

Hackett, EE, Charles-Messance, H, O'Leary, SM, Gleeson, LE, Muñoz-Wolf, N, Case, S, Wedderburn, A, Johnston, DGW, Williams, MA, Smyth, A, Ouimet, M, Moore, KJ, Lavelle, EC, Corr, SC, Gordon, SV, Keane, J & Sheedy, FJ 2020, 'Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21', Cell Reports, vol. 30, no. 1, pp. 124-136.e4. https://doi.org/10.1016/j.celrep.2019.12.015

TY - JOUR

T1 - Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21

AU - Hackett, Emer E.

AU - Charles-Messance, Hugo

AU - O'Leary, Seónadh M.

AU - Gleeson, Laura E.

AU - Muñoz-Wolf, Natalia

AU - Case, Sarah

AU - Wedderburn, Anna

AU - Johnston, Daniel G.W.

AU - Williams, Michelle A.

AU - Smyth, Alicia

AU - Ouimet, Mireille

AU - Moore, Kathryn J.

AU - Lavelle, Ed C.

AU - Corr, Sinéad C.

AU - Gordon, Stephen V.

AU - Keane, Joseph

AU - Sheedy, Frederick J.

PY - 2020/1/7

Y1 - 2020/1/7

N2 - Hackett et al. identify a role for the anti-inflammatory miR-21 in limiting host glycolysis during tuberculosis (TB) infection to favor bacterial replication. This occurs by targeting a pro-glycolytic isoform at the rate-limiting step in glycolysis, PFK-M, a process antagonized by the host Th1-cytokine IFN-γ, to promote full macrophage activation and antimicrobial function.

AB - Hackett et al. identify a role for the anti-inflammatory miR-21 in limiting host glycolysis during tuberculosis (TB) infection to favor bacterial replication. This occurs by targeting a pro-glycolytic isoform at the rate-limiting step in glycolysis, PFK-M, a process antagonized by the host Th1-cytokine IFN-γ, to promote full macrophage activation and antimicrobial function.

KW - glycolysis

KW - interferon gamma

KW - interleukin-1b

KW - macrophage

KW - metabolic reprogramming

KW - microRNA

KW - miR-21

KW - mycobacterium tuberculosis

KW - phosphofructokinase

KW - tuberculosis

UR - https://www.scopus.com/pages/publications/85077314585

U2 - 10.1016/j.celrep.2019.12.015

DO - 10.1016/j.celrep.2019.12.015

M3 - Article

C2 - 31914380

AN - SCOPUS:85077314585

SN - 2639-1856

VL - 30

SP - 124-136.e4

JO - Cell Reports

JF - Cell Reports

IS - 1

ER -

Mycobacterium tuberculosis Limits Host Glycolysis and IL-1β by Restriction of PFK-M via MicroRNA-21

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this