Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration

Aideen M. Sullivan; Jolanta Opacka-Juffry; Jens Pohl; Stavia B. Blunt

doi:10.1016/S0006-8993(98)01275-X

Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration

Aideen M. Sullivan
, Jolanta Opacka-Juffry
, Jens Pohl
, Stavia B. Blunt

Research output: Contribution to journal › Article › peer-review

Abstract

Growth/differentiation factor 5 (GDF5) is a neurotrophin which protects the rat nigrostriatal dopaminergic pathway from 6-hydroxydopamine-induced damage. Here we used amphetamine-induced rotational testing, high- performance liquid chromatography and immunocytochemistry to investigate the minimum effective dose of GDF5. We also compared the effectiveness of injecting GDF5 into either the substantia nigra pars compacta (SNpc), the lateral ventricle (LV) or the striatum (or combinations of these sites).

Original language	English
Pages (from-to)	176-179
Number of pages	4
Journal	Brain Research
Volume	818
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)01275-X
Publication status	Published - 6 Feb 1999
Externally published	Yes

Keywords

6- Hydroxydopamine
Dopamine
Growth/differentiation factor 5
Neuroprotection
Parkinson's disease

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10.1016/S0006-8993(98)01275-X

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title = "Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration",

abstract = "Growth/differentiation factor 5 (GDF5) is a neurotrophin which protects the rat nigrostriatal dopaminergic pathway from 6-hydroxydopamine-induced damage. Here we used amphetamine-induced rotational testing, high- performance liquid chromatography and immunocytochemistry to investigate the minimum effective dose of GDF5. We also compared the effectiveness of injecting GDF5 into either the substantia nigra pars compacta (SNpc), the lateral ventricle (LV) or the striatum (or combinations of these sites).",

keywords = "6- Hydroxydopamine, Dopamine, Growth/differentiation factor 5, Neuroprotection, Parkinson's disease",

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doi = "10.1016/S0006-8993(98)01275-X",

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AU - Sullivan, Aideen M.

AU - Opacka-Juffry, Jolanta

AU - Pohl, Jens

AU - Blunt, Stavia B.

PY - 1999/2/6

Y1 - 1999/2/6

N2 - Growth/differentiation factor 5 (GDF5) is a neurotrophin which protects the rat nigrostriatal dopaminergic pathway from 6-hydroxydopamine-induced damage. Here we used amphetamine-induced rotational testing, high- performance liquid chromatography and immunocytochemistry to investigate the minimum effective dose of GDF5. We also compared the effectiveness of injecting GDF5 into either the substantia nigra pars compacta (SNpc), the lateral ventricle (LV) or the striatum (or combinations of these sites).

AB - Growth/differentiation factor 5 (GDF5) is a neurotrophin which protects the rat nigrostriatal dopaminergic pathway from 6-hydroxydopamine-induced damage. Here we used amphetamine-induced rotational testing, high- performance liquid chromatography and immunocytochemistry to investigate the minimum effective dose of GDF5. We also compared the effectiveness of injecting GDF5 into either the substantia nigra pars compacta (SNpc), the lateral ventricle (LV) or the striatum (or combinations of these sites).

KW - 6- Hydroxydopamine

KW - Dopamine

KW - Growth/differentiation factor 5

KW - Neuroprotection

KW - Parkinson's disease

UR - https://www.scopus.com/pages/publications/0033528280

U2 - 10.1016/S0006-8993(98)01275-X

DO - 10.1016/S0006-8993(98)01275-X

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SN - 0006-8993

VL - 818

SP - 176

EP - 179

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration

Abstract

Keywords

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