Non-AUG translation initiation in mammals

Dmitry E. Andreev; Gary Loughran; Alla D. Fedorova; Maria S. Mikhaylova; Ivan N. Shatsky; Pavel V. Baranov

doi:10.1186/s13059-022-02674-2

Non-AUG translation initiation in mammals

Dmitry E. Andreev
, Gary Loughran
, Alla D. Fedorova
, Maria S. Mikhaylova
, Ivan N. Shatsky
, Pavel V. Baranov

School of Biochemistry and Cell Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.

Original language	English
Article number	111
Journal	Genome Biology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1186/s13059-022-02674-2
Publication status	Published - Dec 2022

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title = "Non-AUG translation initiation in mammals",

abstract = "Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.",

author = "Andreev, \{Dmitry E.\} and Gary Loughran and Fedorova, \{Alla D.\} and Mikhaylova, \{Maria S.\} and Shatsky, \{Ivan N.\} and Baranov, \{Pavel V.\}",

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doi = "10.1186/s13059-022-02674-2",

language = "English",

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T1 - Non-AUG translation initiation in mammals

AU - Andreev, Dmitry E.

AU - Loughran, Gary

AU - Fedorova, Alla D.

AU - Mikhaylova, Maria S.

AU - Shatsky, Ivan N.

AU - Baranov, Pavel V.

PY - 2022/12

Y1 - 2022/12

N2 - Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.

AB - Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within the same RNA. This plurality is often due to the failure of some scanning ribosomes to recognize potential start codons leading to initiation downstream—a process termed leaky scanning. Codons other than AUG (non-AUG) are particularly leaky due to their inefficiency. Here we discuss our current understanding of non-AUG initiation. We argue for a near-ubiquitous role of non-AUG initiation in shaping the dynamic composition of mammalian proteomes.

UR - https://www.scopus.com/pages/publications/85129525769

U2 - 10.1186/s13059-022-02674-2

DO - 10.1186/s13059-022-02674-2

M3 - Review article

C2 - 35534899

AN - SCOPUS:85129525769

SN - 1474-7596

VL - 23

JO - Genome Biology

JF - Genome Biology

IS - 1

M1 - 111

ER -

Non-AUG translation initiation in mammals

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