TY - JOUR
T1 - Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy
AU - Garvey, Aisling A.
AU - O’Neill, Roisin
AU - Livingstone, Vicki
AU - Pavel, Andreea M.
AU - Finn, Daragh
AU - Boylan, Geraldine B.
AU - Murray, Deirdre M.
AU - Dempsey, Eugene M.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Objective: To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE). Study design: Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group. Results: Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming predominantly due to an increase in HR. Conclusion: TH has a significant impact on HR but SV appears largely unaffected. NICOM may provide a non-invasive, continuous, low-cost alternative to monitoring CO in infants with HIE however further research is warranted.
AB - Objective: To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE). Study design: Prospective observational study of 44 infants with HIE (23 mild, 17 moderate, 4 severe) and 17 term controls. Infants with HIE had non-invasive CO monitoring (NICOM) continuously in the neonatal unit. Term controls had NICOM recorded at 6 and 24 h. A mixed-modelling approach was used to assess change in CO over time by group. Results: Infants with moderate HIE have significantly lower CO than the mild group at all timepoints (10.7 mls/kg/min lower, 95% CI:1.0,20.4, p = 0.03) which increases over time, driven by a gradual increase in stroke volume (SV). CO increased further during rewarming predominantly due to an increase in HR. Conclusion: TH has a significant impact on HR but SV appears largely unaffected. NICOM may provide a non-invasive, continuous, low-cost alternative to monitoring CO in infants with HIE however further research is warranted.
UR - https://www.scopus.com/pages/publications/85137486118
U2 - 10.1038/s41372-022-01495-2
DO - 10.1038/s41372-022-01495-2
M3 - Article
C2 - 36056257
AN - SCOPUS:85137486118
SN - 0743-8346
VL - 42
SP - 1622
EP - 1629
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 12
ER -
