Novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells

Charlotte M. Miller; Elaine C. O’sullivan; Florence O. McCarthy

doi:10.3390/ph12020090

Novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells

Charlotte M. Miller
, Elaine C. O’sullivan
, Florence O. McCarthy

School of Chemistry

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6-and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects.

Original language	English
Article number	90
Journal	Pharmaceuticals
Volume	12
Issue number	2
DOIs	https://doi.org/10.3390/ph12020090
Publication status	Published - Jun 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer
Ellipticine
Heterocyclic chemistry
Indole
NCI screen
Topoisomerase II

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10.3390/ph12020090

https://hdl.handle.net/10468/8692Licence: CC BY

Cite this

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title = "Novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells",

abstract = "Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6-and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects.",

keywords = "Anticancer, Ellipticine, Heterocyclic chemistry, Indole, NCI screen, Topoisomerase II",

author = "Miller, \{Charlotte M.\} and O{\textquoteright}sullivan, \{Elaine C.\} and McCarthy, \{Florence O.\}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jun,

doi = "10.3390/ph12020090",

language = "English",

volume = "12",

journal = "Pharmaceuticals",

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T1 - Novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells

AU - Miller, Charlotte M.

AU - O’sullivan, Elaine C.

AU - McCarthy, Florence O.

PY - 2019/6

Y1 - 2019/6

N2 - Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6-and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects.

AB - Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6-and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects.

KW - Anticancer

KW - Ellipticine

KW - Heterocyclic chemistry

KW - Indole

KW - NCI screen

KW - Topoisomerase II

UR - https://www.scopus.com/pages/publications/85069736496

U2 - 10.3390/ph12020090

DO - 10.3390/ph12020090

M3 - Article

AN - SCOPUS:85069736496

SN - 1424-8247

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JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 2

M1 - 90

ER -

Novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells

Abstract

UN SDGs

Keywords

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