TY - CHAP
T1 - Novel combined fluorescence/reflectance spectroscopy system for guiding brain tumor resections - Hardware considerations
AU - Xie, Zhiyuan
AU - Xie, Haiyan
AU - Mousavi, Monirehalsadat
AU - Brydegaard, Mikkel
AU - Axelsson, Johan
AU - Andersson-Engels, Stefan
PY - 2013
Y1 - 2013
N2 - Glioblastoma multiforme (GBM) has long been known as the most common and aggressive form of brain malignancy. The morphological similarities of the malignant and surrounding tissue cause difficulties to distinct the tumors during surgery. In order to achieve better results in resecting malignant brain tumors, a fiber based optical system which can be used intraoperative is developed in this project. In this context, the system hardware details, system controlling interfaces and laboratory testing results are presented. Based on the results obtained from various tests with tissue-equivalent phantoms, the system is proved to have stable performance, robust structure, and have good linearity as well as high sensitivity to low PpIX concentration under strong ambient light conditions.
AB - Glioblastoma multiforme (GBM) has long been known as the most common and aggressive form of brain malignancy. The morphological similarities of the malignant and surrounding tissue cause difficulties to distinct the tumors during surgery. In order to achieve better results in resecting malignant brain tumors, a fiber based optical system which can be used intraoperative is developed in this project. In this context, the system hardware details, system controlling interfaces and laboratory testing results are presented. Based on the results obtained from various tests with tissue-equivalent phantoms, the system is proved to have stable performance, robust structure, and have good linearity as well as high sensitivity to low PpIX concentration under strong ambient light conditions.
KW - Ambient light rejection
KW - Fiber optical probe
KW - Glioblastoma multiforme (GBM)
KW - PpIX fluorescence
KW - Tumor resection
UR - https://www.scopus.com/pages/publications/84891283889
U2 - 10.1117/12.2044717
DO - 10.1117/12.2044717
M3 - Chapter
AN - SCOPUS:84891283889
SN - 9780819499806
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Biophotonics - Riga 2013
T2 - 1st International Conference on Biophotonics - Riga 2013, BPR 2013
Y2 - 26 August 2013 through 31 August 2013
ER -