Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection

Colm Barrett; Finbarr O'Sullivan; Sean Barry; Konstantin Grygoryev; Donal O'Gorman; Conor O'Mahony; Alan O'Riordan

doi:10.1109/SENSORS43011.2019.8956509

Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection

Colm Barrett
, Finbarr O'Sullivan
, Sean Barry
, Konstantin Grygoryev
, Donal O'Gorman
, Conor O'Mahony
, Alan O'Riordan

Dublin City University

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

Abstract

Fabrication and characterization of polymer microneedle arrays, compatible with in-vivo glucose sensing, is described. The process generates a polymer microneedle electrode array comprised of an on-chip working, counter and reference electrodes. Glucose oxidase was entrapped in an o-phenylenediamine/ sulphonated-β-cyclodextrin polymer matrix at working electrodes The sensor array demonstrated glucose detection over the range of 0.5 - 19.5 mM. An interference study and a preliminary cytotoxicity study were carried to assess the sensors potential for future use in interstitial fluid.

Original language	English
Title of host publication	2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781728116341
DOIs	https://doi.org/10.1109/SENSORS43011.2019.8956509
Publication status	Published - Oct 2019
Event	18th IEEE Sensors, SENSORS 2019 - Montreal, Canada Duration: 27 Oct 2019 → 30 Oct 2019

Publication series

Name	Proceedings of IEEE Sensors
Volume	2019-October
ISSN (Print)	1930-0395
ISSN (Electronic)	2168-9229

Conference

Conference	18th IEEE Sensors, SENSORS 2019
Country/Territory	Canada
City	Montreal
Period	27/10/19 → 30/10/19

Keywords

cytotoxicity analysis
glucose sensing
Interstitial fluid
microneedles
pain-free polymer replication

Access to Document

10.1109/SENSORS43011.2019.8956509

Cite this

Barrett, C., O'Sullivan, F., Barry, S., Grygoryev, K., O'Gorman, D., O'Mahony, C., & O'Riordan, A. (2019). Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection. In 2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings Article 8956509 (Proceedings of IEEE Sensors; Vol. 2019-October). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SENSORS43011.2019.8956509

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title = "Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection",

abstract = "Fabrication and characterization of polymer microneedle arrays, compatible with in-vivo glucose sensing, is described. The process generates a polymer microneedle electrode array comprised of an on-chip working, counter and reference electrodes. Glucose oxidase was entrapped in an o-phenylenediamine/ sulphonated-β-cyclodextrin polymer matrix at working electrodes The sensor array demonstrated glucose detection over the range of 0.5 - 19.5 mM. An interference study and a preliminary cytotoxicity study were carried to assess the sensors potential for future use in interstitial fluid.",

keywords = "cytotoxicity analysis, glucose sensing, Interstitial fluid, microneedles, pain-free polymer replication",

author = "Colm Barrett and Finbarr O'Sullivan and Sean Barry and Konstantin Grygoryev and Donal O'Gorman and Conor O'Mahony and Alan O'Riordan",

note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 18th IEEE Sensors, SENSORS 2019 ; Conference date: 27-10-2019 Through 30-10-2019",

year = "2019",

month = oct,

doi = "10.1109/SENSORS43011.2019.8956509",

language = "English",

series = "Proceedings of IEEE Sensors",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

booktitle = "2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings",

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}

Barrett, C, O'Sullivan, F, Barry, S, Grygoryev, K, O'Gorman, D, O'Mahony, C & O'Riordan, A 2019, Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection. in 2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings., 8956509, Proceedings of IEEE Sensors, vol. 2019-October, Institute of Electrical and Electronics Engineers Inc., 18th IEEE Sensors, SENSORS 2019, Montreal, Canada, 27/10/19. https://doi.org/10.1109/SENSORS43011.2019.8956509

Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection. / Barrett, Colm; O'Sullivan, Finbarr; Barry, Sean et al.
2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 2019. 8956509 (Proceedings of IEEE Sensors; Vol. 2019-October).

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

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T1 - Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection

AU - Barrett, Colm

AU - O'Sullivan, Finbarr

AU - Barry, Sean

AU - Grygoryev, Konstantin

AU - O'Gorman, Donal

AU - O'Mahony, Conor

AU - O'Riordan, Alan

PY - 2019/10

Y1 - 2019/10

N2 - Fabrication and characterization of polymer microneedle arrays, compatible with in-vivo glucose sensing, is described. The process generates a polymer microneedle electrode array comprised of an on-chip working, counter and reference electrodes. Glucose oxidase was entrapped in an o-phenylenediamine/ sulphonated-β-cyclodextrin polymer matrix at working electrodes The sensor array demonstrated glucose detection over the range of 0.5 - 19.5 mM. An interference study and a preliminary cytotoxicity study were carried to assess the sensors potential for future use in interstitial fluid.

AB - Fabrication and characterization of polymer microneedle arrays, compatible with in-vivo glucose sensing, is described. The process generates a polymer microneedle electrode array comprised of an on-chip working, counter and reference electrodes. Glucose oxidase was entrapped in an o-phenylenediamine/ sulphonated-β-cyclodextrin polymer matrix at working electrodes The sensor array demonstrated glucose detection over the range of 0.5 - 19.5 mM. An interference study and a preliminary cytotoxicity study were carried to assess the sensors potential for future use in interstitial fluid.

KW - cytotoxicity analysis

KW - glucose sensing

KW - Interstitial fluid

KW - microneedles

KW - pain-free polymer replication

UR - https://www.scopus.com/pages/publications/85078706840

U2 - 10.1109/SENSORS43011.2019.8956509

DO - 10.1109/SENSORS43011.2019.8956509

M3 - Conference proceeding

AN - SCOPUS:85078706840

T3 - Proceedings of IEEE Sensors

BT - 2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 18th IEEE Sensors, SENSORS 2019

Y2 - 27 October 2019 through 30 October 2019

ER -

Barrett C, O'Sullivan F, Barry S, Grygoryev K, O'Gorman D, O'Mahony C et al. Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection. In 2019 IEEE Sensors, SENSORS 2019 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc. 2019. 8956509. (Proceedings of IEEE Sensors). doi: 10.1109/SENSORS43011.2019.8956509

Novel Surface Modified Polymer Microneedle based Biosensors for Interstitial Fluid Glucose Detection

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