Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions

J. Thomsen; N. Bendsøe; K. Svanberg; S. Andersson-Engels; T. M. Jørgensen; L. Thrane; H. E. Larsen; F. Pedersen; P. E. Andersen

doi:10.1117/12.781142

Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions

J. Thomsen
, N. Bendsøe
, K. Svanberg
, S. Andersson-Engels
, T. M. Jørgensen
, L. Thrane
, H. E. Larsen
, F. Pedersen
, P. E. Andersen

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

Abstract

We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT), The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sensitivity and micrometer spatial resolution making it suitable for blood flow measurements in the skin. We demonstrate the ability of detecting blood flow in the human skin using non-interstitial ODT to preserve the non-invasiveness. In general a very limited blood flow activity was observed in normal skin and around skin tumors making monitoring of changes difficult. We suggest solutions to a number of practical issues such as sampling errors and natural fluctuations in flow activity for future work.

Original language	English
Title of host publication	Biophotonics
Subtitle of host publication	Photonic Solutions for Better Health Care
DOIs	https://doi.org/10.1117/12.781142
Publication status	Published - 2008
Externally published	Yes
Event	Biophotonics: Photonic Solutions for Better Health Care - Strasbourg, France Duration: 8 Apr 2008 → 10 Apr 2008

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6991
ISSN (Print)	1605-7422

Conference

Conference	Biophotonics: Photonic Solutions for Better Health Care
Country/Territory	France
City	Strasbourg
Period	8/04/08 → 10/04/08

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Blood flow
Optical coherence tomography
Optical Doppler tomography
Photodynamic therapy
Skin tumors

Access to Document

10.1117/12.781142

Cite this

Thomsen, J., Bendsøe, N., Svanberg, K., Andersson-Engels, S., Jørgensen, T. M., Thrane, L., Larsen, H. E., Pedersen, F., & Andersen, P. E. (2008). Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions. In Biophotonics: Photonic Solutions for Better Health Care Article 699118 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6991). https://doi.org/10.1117/12.781142

@inproceedings{6a0f3d9aa32b459ea19edb0d3aff0a53,

title = "Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions",

abstract = "We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT), The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sensitivity and micrometer spatial resolution making it suitable for blood flow measurements in the skin. We demonstrate the ability of detecting blood flow in the human skin using non-interstitial ODT to preserve the non-invasiveness. In general a very limited blood flow activity was observed in normal skin and around skin tumors making monitoring of changes difficult. We suggest solutions to a number of practical issues such as sampling errors and natural fluctuations in flow activity for future work.",

keywords = "Blood flow, Optical coherence tomography, Optical Doppler tomography, Photodynamic therapy, Skin tumors",

author = "J. Thomsen and N. Bends{\o}e and K. Svanberg and S. Andersson-Engels and J{\o}rgensen, \{T. M.\} and L. Thrane and Larsen, \{H. E.\} and F. Pedersen and Andersen, \{P. E.\}",

year = "2008",

doi = "10.1117/12.781142",

language = "English",

isbn = "9780819471895",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Biophotonics",

note = "Biophotonics: Photonic Solutions for Better Health Care ; Conference date: 08-04-2008 Through 10-04-2008",

}

Thomsen, J, Bendsøe, N, Svanberg, K, Andersson-Engels, S, Jørgensen, TM, Thrane, L, Larsen, HE, Pedersen, F & Andersen, PE 2008, Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions. in Biophotonics: Photonic Solutions for Better Health Care., 699118, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6991, Biophotonics: Photonic Solutions for Better Health Care, Strasbourg, France, 8/04/08. https://doi.org/10.1117/12.781142

Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions. / Thomsen, J.; Bendsøe, N.; Svanberg, K. et al.
Biophotonics: Photonic Solutions for Better Health Care. 2008. 699118 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6991).

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

TY - GEN

T1 - Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions

AU - Thomsen, J.

AU - Bendsøe, N.

AU - Svanberg, K.

AU - Andersson-Engels, S.

AU - Jørgensen, T. M.

AU - Thrane, L.

AU - Larsen, H. E.

AU - Pedersen, F.

AU - Andersen, P. E.

PY - 2008

Y1 - 2008

N2 - We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT), The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sensitivity and micrometer spatial resolution making it suitable for blood flow measurements in the skin. We demonstrate the ability of detecting blood flow in the human skin using non-interstitial ODT to preserve the non-invasiveness. In general a very limited blood flow activity was observed in normal skin and around skin tumors making monitoring of changes difficult. We suggest solutions to a number of practical issues such as sampling errors and natural fluctuations in flow activity for future work.

AB - We investigate vascular changes during Photodynamic therapy (PDT) of skin tumors using optical Doppler tomography (ODT), The effect of vascular shut down on tumor destruction is currently not known, and to optimize treatment it is relevant to investigate this issue further. Optical Doppler tomography is capable of measuring blood flow in biological tissue down to 1-2 mm with sub-mm/s velocity sensitivity and micrometer spatial resolution making it suitable for blood flow measurements in the skin. We demonstrate the ability of detecting blood flow in the human skin using non-interstitial ODT to preserve the non-invasiveness. In general a very limited blood flow activity was observed in normal skin and around skin tumors making monitoring of changes difficult. We suggest solutions to a number of practical issues such as sampling errors and natural fluctuations in flow activity for future work.

KW - Blood flow

KW - Optical coherence tomography

KW - Optical Doppler tomography

KW - Photodynamic therapy

KW - Skin tumors

UR - https://www.scopus.com/pages/publications/44949150217

U2 - 10.1117/12.781142

DO - 10.1117/12.781142

M3 - Conference proceeding

AN - SCOPUS:44949150217

SN - 9780819471895

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Biophotonics

T2 - Biophotonics: Photonic Solutions for Better Health Care

Y2 - 8 April 2008 through 10 April 2008

ER -

Optical Doppler tomography for monitoring vascularization during photodynamic therapy of skin cancer lesions

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this