Parent perceived quality of life is age-dependent in children with food allergy

Background: Food allergy in children significantly affects their quality of life. Its impact can be analyzed by quality of life questionnaires. Objectives: The aim of our study was to validate the French version of disease-specific questionnaires and to evaluate the quality of life in children with IgE-mediated food allergy. Methods: Two validated food allergy-specific questionnaires for quality of life, the parent's and children's forms (FAQLQ-PF and FAQLQ-CF), were translated from English to French and submitted to children with food allergy and their parents. Questionnaires were analyzed in terms of emotional impact, food anxiety, and social and food limitations. NCT 01480427. Results: Sixty-two parents of children aged 0-12yrs answered the FAQLQ-PF, and 32 children aged 8-12yrs the FAQLQ-CF. Construct validity of both questionnaires was assessed by correlation between the FAQLQs and FAIM (r=0.85 and 0.84, respectively). Both FAQLQs had good internal consistency (Cronbach's α=0.748 and 0.67, respectively). Young children (0-3yrs old) showed better quality of life scores than older children (FAQLQ-PF global score: p=0.02). Worse scores were also shown among children with previous severe systemic reactions (FAQLQ-PF global score: p=0.039), the ones with an allergic mother (FAQLQ-PF global score: p=0.002), or allergic siblings (FAQLQ-PF emotional impact score: p=0.034), the ones with multiple food allergy (more than 1 food) (FAQLQ-PF anxiety score: p=0.04) and among the girls (FAQLQ-CF global score: p=0.031). Conclusion: Older children, the ones with severe systemic reactions, or with mothers or siblings also affected by allergies, as well as girls, and children with multiple food allergies show worse quality of life scores.