Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

Sébastien Van De Velde; Stéphane Carryn; Françoise Van Bambeke; Colin Hill; Paul M. Tulkens; Roy D. Sleator

doi:10.1186/1757-4749-1-23

Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

Sébastien Van De Velde
, Stéphane Carryn
, Françoise Van Bambeke
, Colin Hill
, Paul M. Tulkens
, Roy D. Sleator

Research output: Contribution to journal › Article › peer-review

Abstract

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.

Original language	English
Article number	A2
Journal	Gut Pathogens
Volume	1
Issue number	1
DOIs	https://doi.org/10.1186/1757-4749-1-23
Publication status	Published - 15 Dec 2009

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title = "Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes",

abstract = "While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.",

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T1 - Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

AU - Van De Velde, Sébastien

AU - Carryn, Stéphane

AU - Van Bambeke, Françoise

AU - Hill, Colin

AU - Tulkens, Paul M.

AU - Sleator, Roy D.

PY - 2009/12/15

Y1 - 2009/12/15

N2 - While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.

AB - While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem.

UR - https://www.scopus.com/pages/publications/78049418883

U2 - 10.1186/1757-4749-1-23

DO - 10.1186/1757-4749-1-23

M3 - Article

AN - SCOPUS:78049418883

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JO - Gut Pathogens

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IS - 1

M1 - A2

ER -

Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

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